Major Depressive Disorder study: Intracranial electrodes vs TMS
Official title Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans
ClinicalTrials.gov ID: NCT05996900
What this study is testing
- What it's testing
- The study aims to find brain markers that show how repeated transcranial magnetic stimulation (TMS) affects the brain. These markers could help improve TMS treatment for depression and other disorders.
- Who it's for
- Adults who have major depressive disorder or epilepsy and are willing to have brain recordings.
- What's involved
- Participants will receive repeated TMS sessions while researchers record brain activity using both invasive (direct brain electrodes) and noninvasive (surface sensors) methods. They will also undergo related tests and visits.
- Time commitment
- The study lasts several weeks, with multiple TMS sessions and brain recording visits scheduled throughout the period.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- Men and women, ages 18 to 65
- Medication-refractory epilepsy requiring phase II monitoring
- Must have intellectual capacity to ensure adequate comprehension of the study and potential risks involved in order to provide informed consent
- No current or history of major neurological disorders other than epilepsy
You likely can't join if
- Those with a contraindication for MRIs (e.g. implanted metal)
- Any unstable medical condition
- Neurological or uncontrolled medical disease
- Active substance abuse
- Currently pregnant or breastfeeding
The study team makes the final eligibility decision.
Where it is enrolling
- Stanford, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Stanford, California, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.