Alopecia Areata study: Upadacitinib
Official title A Study to Evaluate the Safety and Effectiveness of Upadacitinib Tablets in Adult and Adolescent Participants With Severe Alopecia Areata
ClinicalTrials.gov ID: NCT06012240
What this study is testing
What is Upadacitinib?
An investigational oral tablet being studied for the treatment of severe alopecia areata. is designed to inhibit Janus kinase 1 (JAK1) to modulate immune activity.
Also referred to as Rinvoq, ABT-494.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing whether upadacitinib is safe and works for people with severe alopecia areata. It also looks at how well it is tolerated.
- Who it's for
- You may be able to join if you are an adolescent or adult with severe alopecia areata and can travel to a study site.
- What's involved
- You would take a tablet of upadacitinib or a pretend tablet once a day. You will visit a clinic regularly for exams, blood tests, and questionnaires. Some people may switch to a different dose after 24 or 52 weeks.
- Time commitment
- The study can last up to 160 weeks, with visits at the start, every few weeks, and a final check 30 days after the last tablet.
- Phase 3: a large, late-stage study
- Time commitment: about 160 weeks
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 12 to 63
You may be able to join if
- Adult individuals must be \< 64 years old at Baseline Visit. Where permitted outside United States (US)/European Union (EU), adolescent individuals...
- Diagnosis of severe alopecia areata (AA) with Severity of Alopecia Tool (SALT) score \>= 50 scalp hair loss at Screening and Baseline.
- Severe AA with no spontaneous scalp hair regrowth over the past 6 months.
- Current episode of AA of less than 8 years.
You likely can't join if
- Current diagnosis of primarily diffuse type of AA.
- Current diagnosis of other types of alopecia that would interfere with evaluation of AA, including but not limited to female pattern hair loss, male...
- Diagnosis of other types of inflammatory scalp, eyebrow, or eyelash disorders that would interfere with evaluation of AA as determined by the...
The study team makes the final eligibility decision.
Where it is enrolling
- Fountain Valley, California, United States
- Los Angeles, California, United States
- Sacramento, California, United States
- Thousand Oaks, California, United States
- Boca Raton, Florida, United States
- Hollywood, Florida, United States
- Margate, Florida, United States
- Miami, Florida, United States
- Tampa, Florida, United States
- Indianapolis, Indiana, United States
- New Orleans, Louisiana, United States
- Caledonia, Michigan, United States
- Clarkston, Michigan, United States
- Omaha, Nebraska, United States
- Las Vegas, Nevada, United States
- Reno, Nevada, United States
- New York, New York, United States
- Cleveland, Ohio, United States
- Mason, Ohio, United States
- Portland, Oregon, United States
+ 23 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The study runs about 160 weeks per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, 12 years to 63 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Fountain Valley, California, United States; Los Angeles, California, United States; Sacramento, California, United States; Thousand Oaks, California, United States; Boca Raton, Florida, United States; Hollywood, Florida, United States and 37 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.