Sickle Cell Disease study: Alendronate Sodium
Official title Alendronate for Osteonecrosis in Adults With Sickle Cell Disease
ClinicalTrials.gov ID: NCT06016634
What this study is testing
What is Alendronate Sodium?
An investigational oral medicine being studied as a potential treatment for sickle cell disease–related osteonecrosis. It is designed to inhibit bone‑resorbing cells (osteoclasts) and reduce bone loss.
Also referred to as alendronate tablet, oral alendronate, Fosamax, Binosto.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study aims to find out if alendronate can improve bone health in people with sickle cell disease who have osteonecrosis.
- Who it's for
- Adults who have sickle cell disease and have been diagnosed with osteonecrosis.
- What's involved
- Participants will take oral alendronate tablets and attend study visits for monitoring and tests.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- Age 18-80 years with SCD (any genotype, confirmed by hemoglobin electrophoresis or high performance liquid chromatography)
- Ability to provide written informed consent
- Ability to lay on a dual-energy X-ray absorptiometry (DXA) scanner
- Negative urine pregnancy test for anyone of childbearing potential at study entry
You likely can't join if
- Pregnant women
- Adults unable to consent
- Individuals who are not yet adults (infants, children, teenagers)
- Prisoners
- Hospitalizations (for any cause) within 2 weeks of study entry
The study team makes the final eligibility decision.
Where it is enrolling
- Sacramento, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Sacramento, California, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.