Clinical trial for Obsessive-Compulsive Disorder
Official title tDCS Associated With Symptom Provocation in the Management of Patients With Resistant Obsessive Compulsive Disorder
ClinicalTrials.gov ID: NCT06017713
What this study is testing
- What it's testing
- The study wants to see if 10 daily tDCS sessions, combined with symptom provocation, can reduce OCD symptoms.
- Who it's for
- Adults with severe OCD that has not responded to other treatments.
- What's involved
- Participants will receive a 30‑minute tDCS session each weekday for two weeks, with a small electrical current (2 mA) applied to the brain while a trained staff member helps them focus on their OCD symptoms. They will be evaluated one month and three months after the last session.
- Time commitment
- The study lasts about 12 weeks, including two weeks of daily sessions and follow‑up visits at 1 and 3 months.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70
You may be able to join if
- Patient suffering from OCD evolving for at least 2 years diagnosed according to DSM-V criteria;
- Patient with good insight, defined by a score less than or equal to 18 at the threshold of delusions on the BABS (Brown Assessment of Beliefs Scale)...
- Absence of a current depressive episode (MADRS score \< 21) or suicidal risk (MADRS score item 10 \< 3);
- Absence of epileptic pathology;
- Chronic obsessive-compulsive disorder defined by a total YBOCS score \> 20, or a subscale score \> 15;
You likely can't join if
- Woman of childbearing age without effective means of contraception (hormonal/mechanical: oral, injectable, transcutaneous, implantable, intrauterine...
- Pregnant or nursing woman;
- Patient hospitalized under duress (SPDT, SPDRE);
- Patient under guardianship or curatorship;
- Patient with another DSM-V Axis 1 diagnosis (Schizophrenic Disorder, Bipolar Disorder, Substance Abuse or Substance Dependence).
- Patient suffering from a current depressive episode;
See the full eligibility criteria
- Patient suffering from OCD evolving for at least 2 years diagnosed according to DSM-V criteria;
- Patient with good insight, defined by a score less than or equal to 18 at the threshold of delusions on the BABS (Brown Assessment of Beliefs Scale) insight scale;
- Absence of a current depressive episode (MADRS score \< 21) or suicidal risk (MADRS score item 10 \< 3);
- Absence of epileptic pathology;
- Chronic obsessive-compulsive disorder defined by a total YBOCS score \> 20, or a subscale score \> 15;
- at least 2 antidepressants of the IRS type at an effective dose and for a sufficient duration
- and/or Behavioral and Cognitive therapy for at least 1 year;
- Therapeutic stability (antidepressants) for more than 12 weeks without significant improvement. This treatment, at a fixed dose, will be maintained during the study;
- Patient aged between 18 and 70 included
- Patient who has given his/her informed consent after having received written information on the planned procedure;
- Patient benefiting from social security or by benefiting through a third party.
- Woman of childbearing age without effective means of contraception (hormonal/mechanical: oral, injectable, transcutaneous, implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total oophorectomy)
- Pregnant or nursing woman;
- Patient hospitalized under duress (SPDT, SPDRE);
- Patient under guardianship or curatorship;
- Patient with another DSM-V Axis 1 diagnosis (Schizophrenic Disorder, Bipolar Disorder, Substance Abuse or Substance Dependence).
- Patient suffering from a current depressive episode;
- Patient at risk of suicide;
- Patient with skin lesions on the scalp;
- History of head trauma;
- Patient with an intracerebral metal object
- Patient with a pacemaker;
- Presence of epileptic pathology;
- Patient in an emergency situation or unable to give personal consent
The study team makes the final eligibility decision.
Where it is enrolling
- Poitiers, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Poitiers, France. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.