Acute Myeloid Leukemia study: VIP943
Official title Study of VIP943 in Subjects With Advanced CD123+ Hematologic Malignancies
ClinicalTrials.gov ID: NCT06034275
What this study is testing
What is VIP943 (QW)?
VIP943 is an investigational once‑weekly IV infusion being studied as a potential treatment for acute myeloid leukemia and other CD123+ blood cancers.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study aims to find the highest safe dose of VIP943 and assess its safety and how well it is tolerated.
- Who it's for
- Adults who have advanced acute myeloid leukemia, B‑cell acute lymphoblastic leukemia, or high‑risk myelodysplastic syndrome.
- What's involved
- Participants receive VIP943 at gradually increasing doses and are monitored for side effects through regular visits and tests.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Histologically confirmed AML, B-ALL or MDS. people must have exhausted all available standard therapies or be deemed ineligible for potential...
- Evidence of ≥5% bone marrow or blood blasts (acute leukemia) or ≥5% bone marrow or blood myeloblasts (MDS) to allow for assessment of drug activity.
- Evidence of CD123 expression from a local laboratory.
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2
You likely can't join if
- Known central nervous system (CNS) metastases and/or carcinomatous meningitis.
- Clinically significant cardiac disease including congestive heart failure \> New York Heart Association (NYHA) Class II), evidence for coronary...
The study team makes the final eligibility decision.
Where it is enrolling
- Birmingham, Alabama, United States
- Cincinnati, Ohio, United States
- Nashville, Tennessee, United States
- Houston, Texas, United States
- Seattle, Washington, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Birmingham, Alabama, United States; Cincinnati, Ohio, United States; Nashville, Tennessee, United States; Houston, Texas, United States; Seattle, Washington, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.