Clinical trial for Anal Squamous Cell Carcinoma
Official title MR-Adaptive Radiation Therapy for Anal Cancer With EScalated-Treatment in a Risk-Optimized Approach
ClinicalTrials.gov ID: NCT06050707
What this study is testing
- What it's testing
- The study aims to see if using MR imaging to guide radiation and tailoring the dose to a patient’s risk group improves outcomes, and to find HPV DNA markers that predict how well patients respond and what side‑effects they may have.
- Who it's for
- Adults with anal squamous cell carcinoma who are eligible for radiation therapy.
- What's involved
- Participants will receive MR‑guided radiation treatment, have their HPV DNA tested, and attend scheduled visits for monitoring and follow‑up tests.
- Phase 2: a mid-size study of how well it works
- Time commitment: about 5 years
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Patients with pathologically proven diagnosis of anal SCC. This may include tumors of non-keratinizing histology such as basoloid or cloacogenic...
- Clinical stage T1-4 N0-1 M0 (the Union for International Cancer Control (UICC) / the American Joint Committee on Cancer (AJCC) 8th Ed)
- Patients must be eligible for definitive RT or CRT
- Must be ≥ 18 years of age
- Must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
You likely can't join if
- Previous chemotherapy, RT or curative-intent surgical treatment (i.e. APR) for anal cancer.
- Any previous RT to the abdomino-pelvic region that would result in overlap of RT volume for the current study.
- Individuals with a history of a different malignancy except if they have been disease-free for at least 2 years and are deemed by the investigator to...
The study team makes the final eligibility decision.
Where it is enrolling
- Toronto, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The study runs about 5 years per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Toronto, Ontario, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.