Parkinson Disease study: HV-WALK: High Volume Walking
Official title Moderate Versus High Volume Light-Moderate Intensity Exercise for People With Moderate Parkinson's Disease
ClinicalTrials.gov ID: NCT06088355
What this study is testing
- What it's testing
- The study compares two exercise schedules to see which improves walking speed, overall activity, blood chemistry, and blood vessel stiffness in people with moderate Parkinson’s disease.
- Who it's for
- Veterans with moderate Parkinson’s disease who can walk and follow an exercise program.
- What's involved
- Participants will either exercise a lot for one week each month with a three‑week break, or exercise every week without breaks. They will have regular visits for walking tests, activity monitoring, blood draws, and vascular assessments.
- Time commitment
- The program lasts several months, with visits for testing and exercise sessions scheduled throughout the study period.
- Time commitment: about 52 weeks
Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 and older
You may be able to join if
- MoCA score \>17
- Able to walk with or without an assistive device at least 10 feet
- Best corrected/aided acuity better than 20/70 in the better eye
- Willingness to be assigned by chance to a treatment group
- H\&Y stages 2, 2.5 and 3
You likely can't join if
- Untreated Major Depression and major psychiatric illness
- History of stroke, or traumatic brain injury
- Pure-tone threshold average sensitivity at 0.5, 1.0,and 2.0 kHz exceeds 40 dB
- Alcohol abuse and/or use of antipsychotics
- Planning to leave the area for \>1 month during the study time period.
- Taking moderate to high doses of beta-blockers with a resting heart rate below 60 beats/min given that exercise intensity is measured through target...
See the full eligibility criteria
- MoCA score \>17
- Able to walk with or without an assistive device at least 10 feet
- Best corrected/aided acuity better than 20/70 in the better eye
- Willingness to be assigned by chance to a treatment group
- H\&Y stages 2, 2.5 and 3
- Show clear symptomatic benefit (e.g., alleviated rigidity, bradykinesia, and tremor) from antiparkinsonian medications
- Fluent in English to be able to comprehend and participate; older than 40 years; Diagnosis of definite Parkinson's disease by board certified Movement Disorders Neurologist, using standardized UK Brain Bank criteria
- Untreated Major Depression and major psychiatric illness
- History of stroke, or traumatic brain injury
- Pure-tone threshold average sensitivity at 0.5, 1.0,and 2.0 kHz exceeds 40 dB
- Alcohol abuse and/or use of antipsychotics
- Planning to leave the area for \>1 month during the study time period.
- Taking moderate to high doses of beta-blockers with a resting heart rate below 60 beats/min given that exercise intensity is measured through target heart rate.
- Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina
- Other significant co-morbid disease that would impair ability to participate in the exercise-based intervention, e.g. renal failure on hemodialysis, excessive alcohol use (\>14 drinks per wk)
The study team makes the final eligibility decision.
Where it is enrolling
- Decatur, Georgia, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The study runs about 52 weeks per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Decatur, Georgia, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.