Obesity study: Diet Weight Loss
Official title Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling
ClinicalTrials.gov ID: NCT06129110
What this study is testing
- What it's testing
- The study wants to see if weight loss reduces inflammatory signals from fat inside muscle that may cause insulin resistance and muscle weakness.
- Who it's for
- Adults who are overweight or obese and have insulin resistance or muscle weakness.
- What's involved
- Participants will have body composition, blood, strength tests, and a thigh muscle biopsy before and after a 12‑week diet program that aims to reduce weight.
- Time commitment
- The study lasts about 12 weeks, with two sets of tests and biopsies, one before the diet and one after.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70. Healthy volunteers may be eligible.
You may be able to join if
- Generally healthy men and women aged 18-70
- BMI between 30-40
- Less than 1 hour of exercise per week
- may be pre or post menopausal
You likely can't join if
- Type 1 or Type 2 diabetes
- Thyroid disease
- History of lung disease
- Active use of nicotine
- Severe plasma lipid disorders
- Taking hormone replacement drugs, blood thinners, or thiazoladinediones
See the full eligibility criteria
- Generally healthy men and women aged 18-70
- BMI between 30-40
- Less than 1 hour of exercise per week
- may be pre or post menopausal
- Type 1 or Type 2 diabetes
- Thyroid disease
- History of lung disease
- Active use of nicotine
- Severe plasma lipid disorders
- Taking hormone replacement drugs, blood thinners, or thiazoladinediones
- Currently going through menopause or peri-menopause
- Pregnant or breastfeeding
- History of Polycystic Ovary Syndrome
The study team makes the final eligibility decision.
Where it is enrolling
- Aurora, Colorado, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Aurora, Colorado, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.