Clinical trial for Obesity
Official title A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight
ClinicalTrials.gov ID: NCT06143956
What this study is testing
What is LY3305677?
This is an investigational medicine being studied as a potential treatment for obesity.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing whether new treatments help with long-term weight management. It also checks how safe these treatments are.
- Who it's for
- You may be able to join if you are an adult with obesity or overweight.
- What's involved
- You would get a new treatment for weight management. You would also take part in safety checks.
- Time commitment
- The study lasts for a long time to track weight changes.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 75
You may be able to join if
- Have a body mass index (BMI)
- ≥30 kilogram/square meter (kg/m²), or
- ≥27 kg/m² and \<30 kg/m², or with at least 1 weight-related comorbidity
- Have had a stable body weight for the 3 months prior to randomization (\<5%) body weight gain and/or loss.
You likely can't join if
- Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed \>1 year prior to screening.
- Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma.
- Have poorly controlled hypertension.
- Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease.
- acute myocardial infarction
- cerebrovascular accident (stroke)
See the full eligibility criteria
- Have a body mass index (BMI)
- ≥30 kilogram/square meter (kg/m²), or
- ≥27 kg/m² and \<30 kg/m², or with at least 1 weight-related comorbidity
- Have had a stable body weight for the 3 months prior to randomization (\<5%) body weight gain and/or loss.
- Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed \>1 year prior to screening.
- Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma.
- Have poorly controlled hypertension.
- Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease.
- acute myocardial infarction
- cerebrovascular accident (stroke)
- unstable angina, or
- hospitalization due to congestive heart failure.
- Have a history of symptomatic gallbladder disease within the past 2 years.
- Have a lifetime history of suicide attempts.
The study team makes the final eligibility decision.
Where it is enrolling
- Chandler, Arizona, United States
- Scottsdale, Arizona, United States
- Tucson, Arizona, United States
- Greenbrae, California, United States
- Huntington Park, California, United States
- Rolling Hills Estates, California, United States
- Walnut Creek, California, United States
- Stamford, Connecticut, United States
- Miami, Florida, United States
- Miami Lakes, Florida, United States
- New Port Richey, Florida, United States
- Orlando, Florida, United States
- The Villages, Florida, United States
- Ammon, Idaho, United States
- Chicago, Illinois, United States
- West Des Moines, Iowa, United States
- Topeka, Kansas, United States
- Louisville, Kentucky, United States
- Needham, Massachusetts, United States
- New Bedford, Massachusetts, United States
+ 23 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Chandler, Arizona, United States; Scottsdale, Arizona, United States; Tucson, Arizona, United States; Greenbrae, California, United States; Huntington Park, California, United States; Rolling Hills Estates, California, United States and 37 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.