Clinical trial for Solid Tumors
Official title A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
ClinicalTrials.gov ID: NCT06179160
What this study is testing
What is INCB161734?
INCB161734 is an investigational medicine being studied for the treatment of solid tumors.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study aims to find out how safe and well tolerated INCB161734 is, either by itself or together with other cancer drugs.
- Who it's for
- Adults who have advanced or metastatic solid tumors that carry the KRAS G12D mutation.
- What's involved
- Participants will receive INCB161734 alone or with other anticancer treatments, and will have regular clinic visits and medical tests to monitor safety.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- ≥18 years old.
- Locally advanced or metastatic solid tumor with KRAS G12D mutation.
- For Part 1a and Part 2 Combination Groups 1, 2, and 7: Disease progression on prior standard treatment, intolerance to or ineligibility for standard...
- Cohort specific requirements aas defined in the protocol.
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
You likely can't join if
- Prior treatment with any KRAS G12D inhibitor
- Known additional invasive malignancy within 1 year of the first dose of study drug
- History of organ transplant, including allogeneic stem cell transplantation
- Significant, uncontrolled medical condition
- History or presence of an ECG abnormality
- Inadequate organ function Other protocol-defined Inclusion/Exclusion Criteria may apply
The study team makes the final eligibility decision.
Where it is enrolling
- Phoenix, Arizona, United States
- Palo Alto, California, United States
- Santa Monica, California, United States
- Denver, Colorado, United States
- Sarasota, Florida, United States
- Baltimore, Maryland, United States
- Boston, Massachusetts, United States
- Hackensack, New Jersey, United States
- New York, New York, United States
- Philadelphia, Pennsylvania, United States
- Nashville, Tennessee, United States
- Houston, Texas, United States
- Camperdown, New South Wales, Australia
- Darlinghurst, New South Wales, Australia
- Melbourne, Victoria, Australia
- Nedlands, Western Australia, Australia
- Brussels, Belgium
- Edegem, Belgium
- Leuven, Belgium
- Ottawa, Ontario, Canada
+ 11 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Phoenix, Arizona, United States; Palo Alto, California, United States; Santa Monica, California, United States; Denver, Colorado, United States; Sarasota, Florida, United States; Baltimore, Maryland, United States and 25 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.