Major Depressive Disorder study: AXS-05 vs Bupropion
Official title A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
ClinicalTrials.gov ID: NCT06223880
What this study is testing
What is AXS-05?
AXS-05 is an investigational medicine, taken by mouth, being studied as a potential treatment for major depressive disorder.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing whether AXS‑05 can keep depression from returning compared to bupropion. It looks at how well each treatment works over time.
- Who it's for
- You may be able to join if you have major depression, have responded to AXS‑05, and want to try to stay well.
- What's involved
- You will take either AXS‑05 or bupropion. The study will check your mood over time and you will visit the clinic for check‑ins and share how you feel.
- Time commitment
- The study lasts about six months and includes several clinic visits.
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- Currently meets DSM-5 criteria for diagnosis of MDD without psychotic features
- Current major depressive episode of at least 4 weeks in duration
You likely can't join if
- Previously participated in another clinical study of AXS-05; received any investigational drug or device treatment within 30 days of (Screening)...
- Unable to comply with study procedures
- Medically inappropriate for study participation in the opinion of the investigator
The study team makes the final eligibility decision.
Where it is enrolling
- Bellflower, California, United States
- Lafayette, California, United States
- Oceanside, California, United States
- Redlands, California, United States
- Riverside, California, United States
- San Diego, California, United States
- Upland, California, United States
- Brandon, Florida, United States
- Doral, Florida, United States
- Hialeah, Florida, United States
- Jacksonville, Florida, United States
- Miami, Florida, United States
- Orlando, Florida, United States
- Atlanta, Georgia, United States
- Chicago, Illinois, United States
- Overland Park, Kansas, United States
- New Orleans, Louisiana, United States
- Boston, Massachusetts, United States
- Saint Charles, Missouri, United States
- Las Vegas, Nevada, United States
+ 17 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Bellflower, California, United States; Lafayette, California, United States; Oceanside, California, United States; Redlands, California, United States; Riverside, California, United States; San Diego, California, United States and 31 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.