Clinical trial for Childhood Depression
Official title Neural Mechanisms of Family-Focused Treatment for Youth Depression
ClinicalTrials.gov ID: NCT06289010
What this study is testing
- What it's testing
- The study looks at differences in brain activity and parenting between depressed and non‑depressed children and whether these factors predict how well kids respond to family therapy.
- Who it's for
- Children who have been diagnosed with depression and their parents.
- What's involved
- Participants will fill out questionnaires, have brain scans with fMRI, attend 12 family‑therapy sessions, and have follow‑up visits and another brain scan.
- Time commitment
- The study lasts about 6 months, with 12 therapy sessions and several visits for questionnaires and brain scans.
Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 7 to 12. Healthy volunteers may be eligible.
You may be able to join if
- Have a current DSM-5 diagnosis of MDD, Persistent DD, or DDNOS (based on K-SADS-PL) OR not meet criteria for any DSM-5 mental health diagnosis (based...
- Be ages 7-12
- Be living with a parent(s) or guardian willing to participate
- Not be currently pregnant
- Be able to read, understand consent forms, and provide consent on their child's behalf
You likely can't join if
- Thought or other disturbance in the child that would interfere with the ability to participate in treatment or assessments (e.g., psychotic disorder...
- Severe conduct disorders in the child that threaten the home stability (e.g.
- Youth or primary caregivers do not speak English
- Either parent or child has contraindications for neuroimaging (e.g., claustrophobia, metal implants, braces, electronically, magnetically, or...
- The child is on an antidepressant medication, as it may complicate neuroimaging interpretation.
See the full eligibility criteria
- Have a current DSM-5 diagnosis of MDD, Persistent DD, or DDNOS (based on K-SADS-PL) OR not meet criteria for any DSM-5 mental health diagnosis (based on K-SADS-PL)
- Be ages 7-12
- Be living with a parent(s) or guardian willing to participate
- Not be currently pregnant
- Be able to read, understand consent forms, and provide consent on their child's behalf
- Not have a disturbance that would interfere with participation such as autism spectrum disorder, psychosis, current substance dependence, current use of psychotropic medication, OCD, or MRI contraindication such as...
- Be proficient in English
- Thought or other disturbance in the child that would interfere with the ability to participate in treatment or assessments (e.g., psychotic disorder, autism spectrum disorder, OCD, active substance abuse/dependence...
- Severe conduct disorders in the child that threaten the home stability (e.g. juvenile justice or children's protective service involvement as assessed on KSADS-PL) due to the potential impact on retention
- Youth or primary caregivers do not speak English
- Either parent or child has contraindications for neuroimaging (e.g., claustrophobia, metal implants, braces, electronically, magnetically, or mechanically activated devices such as cochlear implants)
- The child is on an antidepressant medication, as it may complicate neuroimaging interpretation.
The study team makes the final eligibility decision.
Where it is enrolling
- Boston, Massachusetts, United States
- Charlestown, Massachusetts, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 7 years to 12 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Boston, Massachusetts, United States; Charlestown, Massachusetts, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.