PTSD study: RETeval
Official title Biomarkers in the Retina for Prognosticating Mental Health Treatments
ClinicalTrials.gov ID: NCT06363968
What this study is testing
- What it's testing
- The study wants to find out if eye test results change after a single dose of sertraline and if those changes relate to how the eye signals look before treatment.
- Who it's for
- Veterans who have been diagnosed with PTSD and are willing to take sertraline.
- What's involved
- Participants will have an eye test (ERG) before and after taking one dose of sertraline, give information about their PTSD symptoms and treatment history, and may return for another eye test if they start antidepressant treatment later.
- Time commitment
- The study lasts a few days for the initial visits, with an optional follow‑up visit later if the participant begins antidepressant therapy.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 21 to 75
You may be able to join if
- Veteran of the U.S. Armed Forces
- Current diagnosis of PTSD
You likely can't join if
- Known diagnosis of a primary psychotic or major neurocognitive disorder
- Significant bilateral visual loss
- History of acute angle closure glaucoma
- Known inherited retinal disease
- Previous ERG deficits
- Known photosensitive epilepsy
See the full eligibility criteria
- Veteran of the U.S. Armed Forces
- Current diagnosis of PTSD
- Known diagnosis of a primary psychotic or major neurocognitive disorder
- Significant bilateral visual loss
- History of acute angle closure glaucoma
- Known inherited retinal disease
- Previous ERG deficits
- Known photosensitive epilepsy
- Known current pregnancy or lactation
- Allergy or previous adverse reaction to sertraline or SSRI
- Allergy to Sensor Strip gel
- Hepatic failure
- Damage to orbit structure or open lesion in soft tissue surrounding the eye
- Any use in the time period of at least 6 half-lives prior to baseline of sertraline or other drugs acting on serotonin and/or unwillingness to avoid these medications for the duration of the study.
The study team makes the final eligibility decision.
Where it is enrolling
- Seattle, Washington, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 21 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Seattle, Washington, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.