Post Traumatic Stress Disorder study: Tetrahydrocannabinol vs Cannabidiol
Official title Warrior CARE: Cannabis Behavioral Health
ClinicalTrials.gov ID: NCT06381180
What this study is testing
What is Tetrahydrocannabinol?
This is an investigational plant-based medicine being studied as a potential treatment for Post Traumatic Stress Disorder (PTSD). It is designed to interact with the body's endocannabinoid system, which helps regulate mood and stress responses.
Also referred to as THC.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing whether cannabis medicine helps veterans with PTSD and thoughts of suicide.
- Who it's for
- You may be able to join if you are a veteran with PTSD and thoughts of suicide.
- What's involved
- You would be picked by chance to get real medicine or a pretend treatment. You would visit the study team for check-ups.
- Time commitment
- The study lasts for a set time with regular visits to the team.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 19 to 69
You may be able to join if
- a healthy veteran who has served in a branch of the US armed forces
- report using cannabis within the past year
- currently meet DSM-5 criteria for PTSD and a score of 25 or greater on the CAPS-5 (the anchor, or index, trauma does not have to be related to...
- between the ages of 19-69 years old
- not seeking treatment for Cannabis Use Disorder
You likely can't join if
- pregnant, lactating, or heterosexually active women and not using medically approved birth control
- current or past bipolar or psychotic disorder as determined using the SCID-5
- at immediate high risk for suicide based on the C-SSRS
- current SUD other than Nicotine Use Disorder and Alcohol Use Disorder (mild or moderate)
- allergies and/or other contradictions for using cannabis
- any clinically significant medical problems
See the full eligibility criteria
- a healthy veteran who has served in a branch of the US armed forces
- report using cannabis within the past year
- currently meet DSM-5 criteria for PTSD and a score of 25 or greater on the CAPS-5 (the anchor, or index, trauma does not have to be related to military service)
- between the ages of 19-69 years old
- not seeking treatment for Cannabis Use Disorder
- stable (i.e., under the care of a physician or therapist and not experiencing acute symptoms) on psychotropic medications and/or psychotherapy before the study begins (participants can be in treatment for PTSD)
- agree to adhere to study procedures
- pregnant, lactating, or heterosexually active women and not using medically approved birth control
- current or past bipolar or psychotic disorder as determined using the SCID-5
- at immediate high risk for suicide based on the C-SSRS
- current SUD other than Nicotine Use Disorder and Alcohol Use Disorder (mild or moderate)
- allergies and/or other contradictions for using cannabis
- any clinically significant medical problems
- systolic/diastolic BP \>140/90 mmHg or systolic BP \<95 mmHg
- elevated liver function tests
- exhibit cognitive impairment (\<80 IQ)
- enrolled in another clinical trial or have received any drug as part of a research study within 30 days of dosing
- used a prescription medication (with the exception of birth control) within 14 days of study entry that in the opinion of the medically responsible investigator will interfere with the safety of the participant or the...
- unable to provide informed consent
The study team makes the final eligibility decision.
Where it is enrolling
- Detroit, Michigan, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 19 years to 69 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Detroit, Michigan, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.