Obesity study: Insulin
Official title Regional Lipolysis Insulin Regulation
ClinicalTrials.gov ID: NCT06392854
What this study is testing
What is Insulin?
An investigational drug being studied as a potential treatment for obesity. Insulin is designed to lower blood glucose by helping cells take up sugar from the bloodstream.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Researchers want to learn why fat tissue in the belly area reacts differently to insulin compared to lean people.
- Who it's for
- Adults who are obese and carry most of their extra weight around the stomach.
- What's involved
- Participants will have blood tests and other simple measurements to check how their bodies respond to insulin.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65. Healthy volunteers may be eligible.
You may be able to join if
- Males and females 18-65years who are able to comprehend instructions, follow study procedures and who willing to provide written, informed consent...
- Overweight/Obese volunteers will have a BMI 29.0 - 37.0 kg/m2
- Upper body/visceral obesity (UBO) in women will be defined as those with a waist-hip ratio (WHR) \> 0.85 and/or increased visceral fat by single...
- Lower body obesity (LBO) in women will be defined as a waist-hip ratio of \<0.75 and/or a lower visceral fat by single slice CT scan, usually \< 120...
- Are not pregnant or nursing.
You likely can't join if
- Ischemic heart disease
- Atherosclerotic valvular disease
- Persistent blood pressure greater than 160/95 despite antihypertensive medication
- Smokers
- Diagnosis Diabetes Mellitus
- Concomitant use of medications that can alter free fatty acid metabolism, including, but not limited to niacin, thiazolidinediones, beta-blockers...
See the full eligibility criteria
- Males and females 18-65years who are able to comprehend instructions, follow study procedures and who willing to provide written, informed consent will be included.
- Overweight/Obese volunteers will have a BMI 29.0 - 37.0 kg/m2
- Upper body/visceral obesity (UBO) in women will be defined as those with a waist-hip ratio (WHR) \> 0.85 and/or increased visceral fat by single slice CT scan, usually with \> 120 cm2 of visceral fat by CT scanning or a...
- Lower body obesity (LBO) in women will be defined as a waist-hip ratio of \<0.75 and/or a lower visceral fat by single slice CT scan, usually \< 120 cm2 or a visceral fat/total fat ratio of ≤ 0.30 and fasting plasma...
- Are not pregnant or nursing.
- All women of childbearing potential will have a negative urine pregnancy test at screening and a negative urine pregnancy test day of admission for inpatient study visit.
- Ischemic heart disease
- Atherosclerotic valvular disease
- Persistent blood pressure greater than 160/95 despite antihypertensive medication
- Smokers
- Diagnosis Diabetes Mellitus
- Concomitant use of medications that can alter free fatty acid metabolism, including, but not limited to niacin, thiazolidinediones, beta-blockers, oral or injected corticosteroids or anabolic steroids.
- Allergy to lidocaine
- Allergy to indocyanine green.
The study team makes the final eligibility decision.
Where it is enrolling
- Rochester, Minnesota, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Rochester, Minnesota, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.