Clinical trial for Tobacco Use Disorder
Official title Low Intensity Focused Ultrasound for Tobacco Use Disorder: High Resolution Targeting of the Human Insula
ClinicalTrials.gov ID: NCT06405074
What this study is testing
- What it's testing
- This study is testing whether low intensity focused ultrasound (LIFU) applied to a brain area can safely reduce smoking cravings in people with tobacco use disorder.
- Who it's for
- You may be able to join if you are an adult who smokes and has tobacco use disorder.
- What's involved
- You will have a brain scan. Then you will receive a short LIFU session and a pretend (sham) session while looking at smoking pictures. You will answer questions about cravings.
- Time commitment
- The study lasts about one day with a few visits for scans and follow‑up checks.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 75
You may be able to join if
- Male and female veterans aged 18-75 years
- Meet the Diagnostic and Statistical Manual, Fifth edition (DSM-5) criteria for current TUD (moderate to severe) as diagnosed by the Structured...
- Currently smoking \> 10 cigarettes per day with no period of abstinence \> 3 months in the last year
- Current use of tobacco in last year is limited to cigarettes
- Currently in Contemplation Stage of motivation for behavior change with respect to smoking as assessed by the University of Rhode Island Change...
You likely can't join if
- Not under current treatment for smoking cessation.
- No history of head injury, seizures, neurologic disorders including cerebrovascular disease, multiple sclerosis, or neurodegenerative diseases or...
- Current substance use disorder for a psychoactive substance (except nicotine)
- DSM-5 psychiatric disorder requiring current treatment
- Ferromagnetic implants or other contraindications for MRI
- Taking any psychotropic medication such as antidepressants, anxiolytics and antipsychotics.
See the full eligibility criteria
- Male and female veterans aged 18-75 years
- Meet the Diagnostic and Statistical Manual, Fifth edition (DSM-5) criteria for current TUD (moderate to severe) as diagnosed by the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental...
- Currently smoking \> 10 cigarettes per day with no period of abstinence \> 3 months in the last year
- Current use of tobacco in last year is limited to cigarettes
- Currently in Contemplation Stage of motivation for behavior change with respect to smoking as assessed by the University of Rhode Island Change Assessment Scale
- Not under current treatment for smoking cessation.
- No history of head injury, seizures, neurologic disorders including cerebrovascular disease, multiple sclerosis, or neurodegenerative diseases or major medical illness
- Current substance use disorder for a psychoactive substance (except nicotine)
- DSM-5 psychiatric disorder requiring current treatment
- Ferromagnetic implants or other contraindications for MRI
- Taking any psychotropic medication such as antidepressants, anxiolytics and antipsychotics.
- any medication other than psychotropic medications that is known to cross the blood brain barrier and achieve brain penetrance such that it will alter BOLD signal or lower seizure threshold, such as antibiotics...
- currently pregnant or breast feeding
The study team makes the final eligibility decision.
Where it is enrolling
- Washington D.C., District of Columbia, United States
Compensation & support
A stipend or payment for your time may be offered.
No amount is published here because ClinicalTrials.gov has no reliable field for payment or travel support. Ask the study team what's actually covered (payment for your time, travel, parking, or other study costs), and never join a trial for the compensation alone.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team, so confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Washington D.C., District of Columbia, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.