Muscle-Invasive Bladder Carcinoma study: Trimodal therapy
Official title Bladder Preservation for Patients With Muscle Invasive Bladder Cancer (MIBC) With Variant Histology
ClinicalTrials.gov ID: NCT06417190
What this study is testing
What is Trimodal therapy (TMT)?
An investigational treatment approach being studied for muscle-invasive bladder carcinoma with variant histology.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- To see if this combined treatment can be completed within about 45 days after chemotherapy and be a safe option for these patients.
- Who it's for
- People who have muscle‑invasive bladder cancer that shows variant (non‑standard) tumor cells.
- What's involved
- Participants get at least three cycles of chemotherapy, may also receive immunotherapy, then a 4‑ to 6‑week course of chemotherapy given at the same time as radiation therapy.
- Time commitment
- Treatment spans roughly 3–4 months with regular clinic visits for chemo, possible immunotherapy, and daily radiation sessions.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Documented diagnosis of MIBC with variant histology, cT2-T4N0M0, confirmed by TURBT and CT C/A/P and/or PET.
- Written informed consent obtained from subject and ability for subject to comply with the requirements of the study.
You likely can't join if
- Evidence of diffuse cis on pathology
- Presence of bilateral hydronephrosis (if hydronephrosis is present, can only be unilateral)
- Prior radiotherapy to the pelvis
- History of systemic therapy for MIBS
- Presence of concurrent cancer (remote history of cancer (\>5 years) allowed if the patient is without evidence of disease)
The study team makes the final eligibility decision.
Where it is enrolling
- Los Angeles, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Los Angeles, California, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.