Myeloma study: Tocilizumab at emerging CRS
Official title PRONTO Trial (PRophylactic Versus ON-demand Use of TOcilizumab)
ClinicalTrials.gov ID: NCT06430736
What this study is testing
What is Tocilizumab before CAR-T cell infusion?
Tocilizumab before CAR-T cell infusion is an investigational medicine, given as an IV infusion (through a vein), being studied as a potential treatment for myeloma.
Also referred to as Prophylactic.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Despite the consequent use of Tocilizumab together with conventional antipyretics at early/first signs of emerging CRS, CRS (and eventually the subsequent development of ICANS) remain a major concern for patients. This study aims to identify safety and efficacy of prophylactic Tocilizumab treatment.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Patients planned to receive commercial CAR-T treatment for all registered indications comprising lymphomas, leukemias or myeloma at a single academic...
- With written informed consent
- Considered by the investigator to be clinically fit for this treatment
- Patients aged ≥18 years
You likely can't join if
- Previous Tocilizumab treatment within 3 months prior to CAR-T infusion
- Patients with treatment with an investigational compound within 8 weeks prior to CAR-T infusion
- Women who are pregnant or breast feeding, or women intending to become pregnant during the study period
- Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant
- Previous enrolment into the current study
- Enrolment of the investigator, his/her family members, employees and other dependent persons
The study team makes the final eligibility decision.
Where it is enrolling
- Bern, Canton of Bern, Switzerland
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Bern, Canton of Bern, Switzerland. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.