Stimulant Use Disorder study: SUVO vs TAU
Official title Orexin Receptor Antagonism and Sleep in Stimulant Use Disorder
ClinicalTrials.gov ID: NCT06444256
What this study is testing
What is SUVO?
SUVO is an investigational medicine, being studied as a potential treatment for stimulant use disorder.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study wants to find out if suvorexant improves sleep, reduces stress, and lowers drug craving during early abstinence. It also compares how suvorexant versus usual care affects how long patients stay in a residential program and how many finish it.
- Who it's for
- Adults who have a stimulant use disorder and are in early abstinence.
- What's involved
- Participants will receive either suvorexant or the usual care treatment. They will have sleep, stress, and craving assessments and will be monitored during a residential program.
- Time commitment
- The study lasts about 30 days, with visits and assessments during the first 13 days and again from day 13 to day 30 while staying in the residential program.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- Meet Diagnostic and Statistical Manual of Mental Disorders(DSM-5)criteria for primary stimulant use disorder (either cocaine or methamphetamine)
- Be fluent in English and able to understand the consent form
You likely can't join if
- Have an opioid use disorder of any severity
- Have a greater than moderate substance use disorder on any other substance
- Undergoing medication-assisted treatment for withdrawal of any substance
- Have any medical conditions contraindicating SUVO (e.g., severe pulmonary disease, severe cardiovascular disease or clinically abnormal ECG, severe...
- Are currently taking medications with known drug interactions with SUVO (e.g., Monoamine oxidase (MAO) inhibitors, anticonvulsants, haloperidol...
- Are pregnant or breast feeding
See the full eligibility criteria
- Meet Diagnostic and Statistical Manual of Mental Disorders(DSM-5)criteria for primary stimulant use disorder (either cocaine or methamphetamine)
- Be fluent in English and able to understand the consent form
- Have an opioid use disorder of any severity
- Have a greater than moderate substance use disorder on any other substance
- Undergoing medication-assisted treatment for withdrawal of any substance
- Have any medical conditions contraindicating SUVO (e.g., severe pulmonary disease, severe cardiovascular disease or clinically abnormal ECG, severe liver or kidney disease, seizure disorder, or sleep disorder...
- Are currently taking medications with known drug interactions with SUVO (e.g., Monoamine oxidase (MAO) inhibitors, anticonvulsants, haloperidol, phenothiazines, anesthetics, and any sedative)
- Are pregnant or breast feeding
- BMI \> 30 (women only)
- Have a current DSM-5 psychiatric disorder or neurological disease requiring on-going treatment that would make participation unsafe
- Have history of seizure disorder
- Have a head injury with loss of consciousness in the last 5 years
The study team makes the final eligibility decision.
Where it is enrolling
- Houston, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Houston, Texas, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.