Multiple Sclerosis study: Metformin
Official title Metformin as an add-on or Monotherapy in Treatment of Aging People With Multiple Sclerosis (MS)
ClinicalTrials.gov ID: NCT06463743
What this study is testing
What is metformin?
an investigational oral tablet being studied as a potential treatment for older people with multiple sclerosis is designed to lower liver glucose production and improve insulin sensitivity, which may have downstream effects on cellular metabolism
Also referred to as Glucophage.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study aims to find out if metformin is safe and well‑tolerated, and whether it helps protect brain tissue in older people with MS compared to placebo.
- Who it's for
- Older adults who have been diagnosed with multiple sclerosis.
- What's involved
- Participants will take a daily extended‑release metformin pill (or a placebo) and undergo regular check‑ups and brain MRI scans to monitor safety and brain changes.
- Time commitment
- The trial lasts about 9 months and includes periodic clinic visits and MRI scans during that time.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 55 to 75
You may be able to join if
- age between 55 and 75 years old
- having a diagnosis of MS based on the latest McDonald criteria
- non-active disease course (no relapses and no MRI activity) in the last 2 years as determined by the MS provider and based on the 2020 revised...
- EDSS score \<7.0
You likely can't join if
- inability to undergo MRI scans
- inability to participate in the study during the study period
- diabetes or uncontrolled cardiovascular disease
- unable to consent
The study team makes the final eligibility decision.
Where it is enrolling
- Buffalo, New York, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 55 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Buffalo, New York, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.