Parkinson Disease study: EVS and EEG
Official title Vestibular and Cortical Contributions to Transitions in Freezing of Gait in Parkinson's Disease
ClinicalTrials.gov ID: NCT06506058
What this study is testing
- What it's testing
- The study aims to learn how the inner‑ear balance system and brain activity contribute to freezing of gait during movement changes, and to find brain signals that mark these episodes.
- Who it's for
- Adults with Parkinson's disease, whether they experience freezing of gait or not.
- What's involved
- Participants will have a mild electrical stimulus to the balance system (electrical vestibular stimulation) and wear an EEG cap to record brain activity while they stand, walk, turn, and change speed.
- Time commitment
- The study involves several testing sessions over a period of weeks, each including the stimulation or EEG recordings and brief movement tasks.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 21 to 80. Healthy volunteers may be eligible.
You may be able to join if
- Participants with Parkinson's disease (with and without Freezing of Gait)
- Diagnosis of idiopathic PD.
- Age 40-80 years.
- Able to ambulate independently without the use of an assistive device (e.g. cane) for 50 meters. Healthy Older Adults (Control participants)
- Age 40-80 years (this group will be age- and sex-matched to the PD and FOG group).
You likely can't join if
- Any musculoskeletal disorder that affects the ability to stand or walk.
- History of musculoskeletal disorders that significantly affect movement of lower limbs.
- Uncorrected visual impairment that may affect participation or performance in the study.
- History of visual and/or vestibular conditions that may affect participation or performance in the study.
- Meet criteria for dementia with Lewy bodies, Multiple Systems Atrophy, Alzheimer's disease, dementia diagnosis, or other neurodegenerative disorder...
- History of seizures, epilepsy, stroke, multiple sclerosis, or traumatic brain injury or other significant neurological disorders that may affect...
See the full eligibility criteria
- Participants with Parkinson's disease (with and without Freezing of Gait)
- Diagnosis of idiopathic PD.
- Age 40-80 years.
- Able to ambulate independently without the use of an assistive device (e.g. cane) for 50 meters. Healthy Older Adults (Control participants)
- Age 40-80 years (this group will be age- and sex-matched to the PD and FOG group).
- Able to ambulate independently without the use of an assistive device (cane or walker).
- Normal capacity to perform complex activities of daily living independently based on informant or physician report. Healthy Young Adults
- Age 21-44 years (this group will be sex-matched to the PD and FOG group)
- Able to ambulate independently without the use of an assistive device (cane or walker)
- Any musculoskeletal disorder that affects the ability to stand or walk.
- History of musculoskeletal disorders that significantly affect movement of lower limbs.
- Uncorrected visual impairment that may affect participation or performance in the study.
- History of visual and/or vestibular conditions that may affect participation or performance in the study.
- Meet criteria for dementia with Lewy bodies, Multiple Systems Atrophy, Alzheimer's disease, dementia diagnosis, or other neurodegenerative disorder other than Parkinson's disease.
- History of seizures, epilepsy, stroke, multiple sclerosis, or traumatic brain injury or other significant neurological disorders that may affect participation or performance in the study.
- History of muscular conditions of the neck and back, including whiplash.
- History of surgery on blood vessels, brain, or heart.
- Unexplained, recurring headaches or concussion within the last six months.
- Moderate to severe hearing impairment.
- people who are pregnant
- History of motion sickness (as EVS can exacerbate motion sickness).
- Intense physical exercise or consumption of alcohol in the 24 hours prior to any experiment that will include EVS testing.
- Recent history of migraine headaches.
- Intracranial metallic or magnetic devices.
- Pacemaker or any implanted device.
- Implanted deep brain stimulator or other neurosurgeries to treat PD.
- Presence of parkinsonism or cognitive impairment (including dementia or mild cognitive impairment).
- Active central nervous system, systemic, psychiatric conditions or use of psychoactive medication that would adversely affect cognitive, neuropsychiatric, motor, or autonomic functioning.
The study team makes the final eligibility decision.
Where it is enrolling
- Minneapolis, Minnesota, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 21 years to 80 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Minneapolis, Minnesota, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.