Central Sleep Apnea Comorbid With Opioid Use study: Acetazolamide
Official title Acetazolamide in Central Sleep Apnea Patients Using Medication for Opioid Use Disorder
ClinicalTrials.gov ID: NCT06521476
What this study is testing
What is Acetazolamide?
This is an investigational oral medicine being studied to see if it can help with central sleep apnea caused by opioid use disorder medications. It is designed to change the body's acid balance to stimulate breathing during sleep.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study will see whether acetazolamide improves breathing during sleep and changes related health measures in people whose opioid treatment causes central sleep apnea.
- Who it's for
- Adults who are taking methadone or buprenorphine for opioid use disorder and have central sleep apnea.
- What's involved
- Participants will receive either acetazolamide or a placebo for 7 days, then have an overnight sleep study and other health tests to measure breathing, sleep quality, anxiety, and drug craving.
- Time commitment
- The study lasts 7 days of medication plus one overnight sleep study visit, with additional tests before and after the medication period.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 100
You may be able to join if
- Patients on Medication for Opioid Use Disorder (MOUD) with central sleep apnea.
You likely can't join if
- Sleep-related Hypoventilation.
- Other causes of Central Sleep Apnea besides Opioid Use.
- Pregnancy.
- Contraindications for Acetazolamide.
The study team makes the final eligibility decision.
Where it is enrolling
- Pittsburgh, Pennsylvania, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 100 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Pittsburgh, Pennsylvania, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.