NASH - Nonalcoholic Steatohepatitis study: Efruxifermin
Official title A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH
ClinicalTrials.gov ID: NCT06528314
What this study is testing
What is Efruxifermin?
An investigational once‑daily subcutaneous injection being studied as a potential treatment for nonalcoholic steatohepatitis (NASH) with compensated cirrhosis.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study aims to evaluate the effects of efruxifermin compared with placebo in people with compensated cirrhosis due to NASH or MASH.
- Who it's for
- Adults who have compensated cirrhosis caused by NASH or MASH.
- What's involved
- Participants will receive either efruxifermin or a placebo and will attend scheduled clinic visits for treatment administration and health assessments.
- Phase 3: a large, late-stage study
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- Cohort 1: Biopsy proven compensated cirrhosis (fibrosis stage 4) due to NASH/MASH and NAS score of \>=3 (at least 1 in each category) or evidence of...
- Cohort 2: Biopsy proven or non-invasively diagnosed compensated cirrhosis (fibrosis stage 4) due to NASH/MASH
You likely can't join if
- Other causes of liver disease based on medical history and/or liver histology and/or central laboratory results
- Type 1 diabetes or unstable Type 2 diabetes
- Any current or prior history of decompensated liver disease Other inclusion and exclusion criteria may apply.
The study team makes the final eligibility decision.
Where it is enrolling
- Birmingham, Alabama, United States
- Dothan, Alabama, United States
- Chandler, Arizona, United States
- Peoria, Arizona, United States
- Scottsdale, Arizona, United States
- Tucson, Arizona, United States
- Little Rock, Arkansas, United States
- North Little Rock, Arkansas, United States
- Coronado, California, United States
- Escondido, California, United States
- Folsom, California, United States
- Fountain Valley, California, United States
- Lancaster, California, United States
- Long Beach, California, United States
- Los Angeles, California, United States
- Newport Beach, California, United States
- Orange, California, United States
- Pasadena, California, United States
- Redwood City, California, United States
- Sacramento, California, United States
+ 265 more site(s).
Compensation & support
A stipend or payment for your time may be offered.
No amount is published here because ClinicalTrials.gov has no reliable field for payment or travel support. Ask the study team what's actually covered (payment for your time, travel, parking, or other study costs), and never join a trial for the compensation alone.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team, so confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Birmingham, Alabama, United States; Dothan, Alabama, United States; Chandler, Arizona, United States; Peoria, Arizona, United States; Scottsdale, Arizona, United States; Tucson, Arizona, United States and 279 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.