Tobacco Use Disorder study: Nicotine replacement
Official title Transcranial Magnetic Stimulation for Nicotine Dependence: An Effectiveness-Implementation Trial
ClinicalTrials.gov ID: NCT06534047
What this study is testing
What is Nicotine Replacement Therapy?
An investigational nicotine replacement therapy being studied for tobacco use disorder. is designed to deliver controlled amounts of nicotine to reduce withdrawal symptoms and cravings.
Also referred to as NRT.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study compares how well rTMS works for quitting smoking compared to standard treatment, and looks at how easy it is to use in regular clinics.
- Who it's for
- Adults who smoke and have a psychiatric disorder.
- What's involved
- Participants will receive either the rTMS treatment or the usual smoking‑cessation care, with scheduled clinic visits and related tests.
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70
You may be able to join if
- Able to provide informed consent.
- Age 18-70.
- Self-reported daily tobacco cigarette consumption.
- Meet DSM-5 criteria for a psychiatric disorder that includes one of the following: mood disorders (e.g.
- Interested in using either Repetitive Transcranial Magnetic Stimulation (rTMS) or nicotine replacement therapy as a smoking cessation treatment.
You likely can't join if
- Contraindication to rTMS according to the TMS Adult Safety Screen (TASS) and PI review.
- Have any intracranial implant (e.g., aneurysm clips) or any other metal object within or near the head, excluding the mouth, that cannot be safely...
- Pregnant or intending to be pregnant during the study.
- A history of a primary seizure disorder, seizure associated with an intracranial lesion, recurrent seizures related to substance intoxication or...
- Space occupying intracranial lesion.
- Any generalized skin disorders precluding the use of the nicotine patch.
See the full eligibility criteria
- Able to provide informed consent.
- Age 18-70.
- Self-reported daily tobacco cigarette consumption.
- Meet DSM-5 criteria for a psychiatric disorder that includes one of the following: mood disorders (e.g. major depressive disorder, bipolar disorder), anxiety disorders (e.g.
- Interested in using either Repetitive Transcranial Magnetic Stimulation (rTMS) or nicotine replacement therapy as a smoking cessation treatment.
- Intending on quitting smoking within the next 30 days.
- Contraindication to rTMS according to the TMS Adult Safety Screen (TASS) and PI review.
- Have any intracranial implant (e.g., aneurysm clips) or any other metal object within or near the head, excluding the mouth, that cannot be safely removed.
- Pregnant or intending to be pregnant during the study.
- A history of a primary seizure disorder, seizure associated with an intracranial lesion, recurrent seizures related to substance intoxication or withdrawal or recent seizure within the last 6 months.
- Space occupying intracranial lesion.
- Any generalized skin disorders precluding the use of the nicotine patch.
- Any known hypersensitivity or allergies to the nicotine patch.
- Any known life-threatening arrhythmias or severe/worsening angina pectoris.
- Within two weeks of experiencing a myocardial infarction or cerebral vascular accident.
- Currently using or has used nicotine replacement therapy within the past two weeks.
- Diagnosed with a terminal illness
- Current regular use of e-cigarettes or other vaping devices containing nicotine and not willing to stop using these devices for the duration of the study.
- Acutely unstable medical, psychiatric, or substance use disorder comorbidity with safety concerns at the discretion of the PI or study physician.
- Previous treatment with rTMS for smoking cessation
- Treatment with nicotine replacement therapy anytime within the last 1 month
The study team makes the final eligibility decision.
Where it is enrolling
- Toronto, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Toronto, Ontario, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.