Clinical trial for Multiple Sclerosis
Official title Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension
ClinicalTrials.gov ID: NCT06554340
What this study is testing
- What it's testing
- The study will find out whether a 12‑week home cycling program can lower blood pressure and improve cognition and walking ability compared with a stretching program in people with multiple sclerosis who have high blood pressure.
- Who it's for
- Adults with multiple sclerosis who also have hypertension.
- What's involved
- Participants will be randomly assigned to either a home‑based cycling exercise program or a stretching program for 12 weeks, and will attend two lab visits for tests of blood pressure, thinking skills, walking and fitness.
- Time commitment
- The study lasts about 13‑14 weeks and requires two lab visits, one at the start and one at the end.
Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Persons with confirmed multiple sclerosis diagnosis with Expanded Disability Status Scale scores of 4-6.5, characteristic of 2nd stage of multiple...
- Hypertension defined as elevated, or Stage 1 or 2, as per the 2017 American Heart Association guidelines (brachial systolic blood pressure \> 120...
- Persons who are physically inactive (less than 60 min/wk of physical activity);
- Persons with body mass index \< 40 kg/m2;
- Persons who are not confined to a wheel chair;
You likely can't join if
- People with additional cardiovascular comorbidities;
- People with type 1 diabetes mellitus;
- Physician disapproval to participating in the study;
- Space constraints to fit a cycle ergometer at the home of prospective participants.
See the full eligibility criteria
- Persons with confirmed multiple sclerosis diagnosis with Expanded Disability Status Scale scores of 4-6.5, characteristic of 2nd stage of multiple sclerosis;
- Hypertension defined as elevated, or Stage 1 or 2, as per the 2017 American Heart Association guidelines (brachial systolic blood pressure \> 120 mmHg or brachial diastolic blood pressure \> 80 mmHg)
- Persons who are physically inactive (less than 60 min/wk of physical activity);
- Persons with body mass index \< 40 kg/m2;
- Persons who are not confined to a wheel chair;
- Multiple sclerosis relapse in the past 30 days;
- People with stable pharmacotherapy.
- People with additional cardiovascular comorbidities;
- People with type 1 diabetes mellitus;
- Physician disapproval to participating in the study;
- Space constraints to fit a cycle ergometer at the home of prospective participants.
The study team makes the final eligibility decision.
Where it is enrolling
- Boston, Massachusetts, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Boston, Massachusetts, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.