Clinical trial for Healthy
Official title Neuromodulation of Brain and Emotional Responses to Psychological Stress
ClinicalTrials.gov ID: NCT06603064
What this study is testing
- What it's testing
- This study is testing whether a gentle brain zap tool changes how you feel stress. It looks at how your brain reacts to stress with and without the tool.
- Who it's for
- You may be able to join if you are healthy and do not have anxiety.
- What's involved
- You would lie in a brain scanner while doing tasks. You would get a real brain zap or a pretend one at two visits.
- Time commitment
- You would need to come in for two visits to get the treatment and scans.
Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 30 to 50. Healthy volunteers may be eligible.
You may be able to join if
- Medication Use a. The following medications can affect brain and cardiovascular measures being obtained in this study
- Anyone reporting 35 or more alcoholic drinks in the last 7 days is excluded.
- Anyone reporting consumption of 6 or more alcoholic drinks on 3 or more occasions in the past 7 days is excluded.
- Anyone reporting use of illicit drugs on 7 or more days in the past 2 weeks is excluded.
- Epilepsy or a history of seizures.
See the full eligibility criteria
- Medication Use a. The following medications can affect brain and cardiovascular measures being obtained in this study
- Anyone reporting 35 or more alcoholic drinks in the last 7 days is excluded.
- Anyone reporting consumption of 6 or more alcoholic drinks on 3 or more occasions in the past 7 days is excluded.
- Anyone reporting use of illicit drugs on 7 or more days in the past 2 weeks is excluded.
- Epilepsy or a history of seizures.
- Self-reported prior heart attack, stroke, bypass surgery, angioplasty, congestive heart failure, arrhythmia (cardiac rhythm problems).
- Severe hypertension (SBP/DBP \> 160/and/or \>100 mmHg)
- Cancer (treatment in last 12 months, allowances for non-melanoma skin cancer)
- Liver disease
- Kidney disease
- Type I diabetes
- Self-reported history of a major neurological disorder or brain injury resulting in ongoing symptoms or cognitive impairment (e.g., multiple sclerosis, cerebral palsy, major head injury)
- Self-reported chronic psychotic illness (schizophrenia, bipolar disorder)
- Lung disease requiring drug treatment (note however that asthma or allergy inhalers are not exclusionary unless they are used on a "regular basis")
- Pregnant participants, or participants actively planning to become pregnant in the next 3 months, are excluded.
- Those with a visual impairment that would prevent them from reading printed text or text on a computer screen, iPad, or other electronic device are excluded.
- Those with color blindness, who may not be able to distinguish colors on some of the tasks used in this study, are excluded.
- Those who report that they are not comfortable with undergoing MRI because of the confined space would be excluded.
- Those who use certain medical devices, implants, or other metal objects in or on the body that cannot be removed and are incompatible with use of fMRI (for example, tattooed eyeliner) are excluded.
- Those who are unable to fit into an MRI scanner (over 7ft2in tall or greater than 350lbs weight) are excluded.
- Those who report working the night shift on a frequent basis (half or more of the hours worked in a full workday are between midnight and 8 am, and this has occurred more than 12 times during the past year) are excluded.
- Those who report undergoing brain stimulation procedures (including transcranial magnetic stimulation, transcranial direct current stimulation, vagus nerve stimulation, or transcranial ultrasound stimulation) as part of...
- Lifetime history of a suicide attempt, or suicidal ideation within the past year.
The study team makes the final eligibility decision.
Where it is enrolling
- Pittsburgh, Pennsylvania, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 30 years to 50 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Pittsburgh, Pennsylvania, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.