Respiratory Failure study: Routine ECMO vs On-demand ECMO
Official title Routine vs On-demand ECMO for Lung Transplantation
ClinicalTrials.gov ID: NCT06615492
What this study is testing
- What it's testing
- The study wants to see if routine use of ECMO during lung transplant improves outcomes compared to using it only when the patient’s oxygen levels drop.
- Who it's for
- Adults who are scheduled for a lung transplant because of serious lung conditions such as COPD, interstitial lung disease, pulmonary fibrosis, or respiratory failure.
- What's involved
- Participants will receive either routine ECMO support during the transplant or ECMO only if their oxygen levels fall. They will have the usual transplant surgery, plus the assigned ECMO strategy, and will undergo standard post‑operative care and monitoring.
- Time commitment
- The study lasts through the transplant surgery and the immediate recovery period, with follow‑up visits as scheduled by the transplant team.
Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Patients undergoing lung transplant surgery
You likely can't join if
- Inability to provide consent for the study
- Retransplantation
- Multi-organ transplantation
- Contra-indication to standard heparin anticoagulation (e.g., heparin-induced thrombocytopenia)
- Systolic pulmonary artery pressure (PAP) ≥ 80 mm Hg on the most recent echocardiography, right heart catheterization, or pulmonary artery catheter...
- Mean PAP ≥ 55 mm Hg on the most recent echocardiography, right heart catheterization, or pulmonary artery catheter measurement
See the full eligibility criteria
- Patients undergoing lung transplant surgery
- Inability to provide consent for the study
- Retransplantation
- Multi-organ transplantation
- Contra-indication to standard heparin anticoagulation (e.g., heparin-induced thrombocytopenia)
- Systolic pulmonary artery pressure (PAP) ≥ 80 mm Hg on the most recent echocardiography, right heart catheterization, or pulmonary artery catheter measurement
- Mean PAP ≥ 55 mm Hg on the most recent echocardiography, right heart catheterization, or pulmonary artery catheter measurement
- The ratio of mean pulmonary to systemic artery pressure of \> 0.66
- Moderate to severe right ventricular (RV) hypokinesis or dysfunction
- Left ventricular dysfunction: Defined as ejection fraction (LVEF) less than 45% on echocardiography, ventriculography, computed tomography (CT), or magnetic resonance imaging (MRI)
- Patients requiring concomitant cardiac surgery: For example, significant coronary artery disease (CAD) requiring surgical grafting
The study team makes the final eligibility decision.
Where it is enrolling
- Montreal, Quebec, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Montreal, Quebec, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.