Diabetic Peripheral Neuropathic Pain study: VX-993 vs Pregabalin
Official title Evaluation of Efficacy and Safety of VX-993 for Pain Associated With Diabetic Peripheral Neuropathy
ClinicalTrials.gov ID: NCT06619860
What this study is testing
What is VX-993?
VX-993 is an investigational medicine, taken by mouth, being studied as a potential treatment for diabetic peripheral neuropathic pain.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study will look at how well VX‑993 works, how safe it is, and how well people can tolerate it for pain caused by diabetic peripheral neuropathy.
- Who it's for
- People who have pain from diabetic peripheral neuropathy.
- What's involved
- Participants will receive VX‑993 and will have regular visits and tests to monitor pain, safety, and tolerability.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- Diagnosis of diabetes mellitus type 1 or type 2 with
- Glycosylated hemoglobin A1c (HbA1c) less than or equal to (≤) 9% and
- Presence of bilateral pain in lower extremities due to DPN (defined as a symmetric, length-dependent sensory or sensorimotor polyneuropathy) for at...
You likely can't join if
- Painful neuropathy other than DPN
- History of cardiac dysrhythmias requiring anti-arrhythmia treatment(s)
- History of a clinical atherosclerotic event, such as myocardial infarction or stroke, within the past 12 months Other protocol defined...
The study team makes the final eligibility decision.
Where it is enrolling
- Brampton, Canada
- Kelowna, Canada
- Montreal, Canada
- Toronto, Canada
- Clermont-Ferrand, France
- Nîmes, France
- Paris, France
- Saint-Priest-en-Jarez, France
- Bad Oeynhausen, Germany
- Berlin, Germany
- Offenbach/Main, Germany
- Milan, Italy
- Birmingham, United Kingdom
- Dundee, United Kingdom
- Glasgow, United Kingdom
- Liverpool, United Kingdom
- London, United Kingdom
- Manchester, United Kingdom
- Nuneaton, United Kingdom
- Sheffield, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Brampton, Canada; Kelowna, Canada; Montreal, Canada; Toronto, Canada; Clermont-Ferrand, France; Nîmes, France and 14 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.