Post-Traumatic Stress Disorders study: Working Memory Training
Official title Cognitive Control Training for Extinction in PTSD
ClinicalTrials.gov ID: NCT06629064
What this study is testing
- What it's testing
- This study is testing whether working memory training can improve how well veterans with PTSD can learn to stop feeling afraid. It also looks at brain changes that might explain this effect.
- Who it's for
- You may be able to join if you are a veteran who has PTSD and can attend the study sessions.
- What's involved
- You will do computer games that train your memory. You will also have brain scans and questionnaires to see how you feel and how your brain changes.
- Time commitment
- The study lasts several weeks and includes multiple visits for training, scans, and follow‑up assessments.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- Fluent in English
- Meet current DSM-5 criteria for Posttraumatic Stress Disorder
- Are willing to attend 8 total remote sessions of working memory training over course of four weeks
- Are willing to attend MRI scans pre and post working memory training
- 4-week stability on pharmacological and psychosocial treatments
You likely can't join if
- A lifetime history of psychotic disorders, lifetime history of bipolar disorder
- Past-year severe substance use and severe alcohol use disorder. Mild-to-moderate alcohol use disorder will be allowed to enhance generalizability in...
- History of any neurological disorder that might be associated with cognitive dysfunction (e.g., cerebrovascular accident, intracranial surgery...
- Acute suicidality requiring immediate clinical intervention
- Moderate to severe traumatic brain injury (TBI). However, mild to moderate levels of TBI (mTBI) will be included
- Receiving benzodiazepines or medications with anticholinergic effects that may affect fear learning measures
See the full eligibility criteria
- Fluent in English
- Meet current DSM-5 criteria for Posttraumatic Stress Disorder
- Are willing to attend 8 total remote sessions of working memory training over course of four weeks
- Are willing to attend MRI scans pre and post working memory training
- 4-week stability on pharmacological and psychosocial treatments
- A lifetime history of psychotic disorders, lifetime history of bipolar disorder
- Past-year severe substance use and severe alcohol use disorder. Mild-to-moderate alcohol use disorder will be allowed to enhance generalizability in our sample due to the high comorbidity of alcohol use and PTSD
- History of any neurological disorder that might be associated with cognitive dysfunction (e.g., cerebrovascular accident, intracranial surgery, aneurysm, seizure disorder)
- Acute suicidality requiring immediate clinical intervention
- Moderate to severe traumatic brain injury (TBI). However, mild to moderate levels of TBI (mTBI) will be included
- Receiving benzodiazepines or medications with anticholinergic effects that may affect fear learning measures
- Inability to safely complete fMRI session (i.e., metal in body, medical implants)
The study team makes the final eligibility decision.
Where it is enrolling
- San Diego, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at San Diego, California, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.