Clinical trial for Posttraumatic Stress Disorder (PTSD)
Official title Inflammatory Challenge and Fear
ClinicalTrials.gov ID: NCT06630884
What this study is testing
What is Typhoid VI Polysaccharide Vaccine Injectable Solution?
This is an investigational vaccine being studied to see if it changes how people with PTSD process fear and information. It is designed to stimulate the immune system to produce a short-term change in immune activity.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing whether a typhoid vaccine changes how people with PTSD process fear and emotions. It also looks at how the vaccine affects their thoughts and feelings.
- Who it's for
- You may be able to join if you have PTSD and live in the San Francisco area.
- What's involved
- You will visit the VA clinic four times. At one visit you will get either a typhoid vaccine or a pretend saline shot. During a visit you will listen to sounds while your body’s reactions are measured. You will also fill out questionnaires and do some simple tests.
- Time commitment
- The study lasts about a month, with four clinic visits and some time for tests and questionnaires at each visit.
- Phase 1: an early, usually small safety study
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65. Healthy volunteers may be eligible.
You may be able to join if
- Aged 18-65 years old
- Trauma Exposed
- Current PTSD/No history of PTSD
You likely can't join if
- Contraindications to typhoid vaccine
- Conditions associated with inflammation
- Pregnancy or plans to become pregnant in next three months
The study team makes the final eligibility decision.
Where it is enrolling
- San Francisco, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at San Francisco, California, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.