Opioid Use Disorder study: MemFlex
Official title Autobiographical Memory in Opioid Use Disorder
ClinicalTrials.gov ID: NCT06643988
What this study is testing
- What it's testing
- The study wants to see if memory training can help people with opioid use disorder and how brain and heart activity relate to memory and symptoms.
- Who it's for
- It is looking for adults who have opioid use disorder and a small group of healthy volunteers.
- What's involved
- Participants will do a baseline test, then four weeks of at‑home memory training called MemFlex, and a follow‑up test. Each visit includes a urine drug test, brain scans with a near‑infrared device, and a wristband that records heartbeats.
- Time commitment
- The study lasts about five weeks, with a baseline visit, four weekly at‑home training sessions, and a final follow‑up visit.
You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 60. Healthy volunteers may be eligible.
You may be able to join if
- Age 18 years to 60 years old.
- Willingness to provide signed, informed consent and commit to completing study procedures
- people must be willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures, and must have access...
- OUD people: Lifetime self-reported history of OUD (according to DSM-5 criteria)
- OUD people: On a stable dose (at least 2 weeks without change) of MOUD (e.g., buprenorphine, methadone) as confirmed by self-report, urine drug...
You likely can't join if
- Current severe psychiatric (e.g., bipolar disorder) or physical (e.g., dementia, Parkinson's disease) determined by self-reported history or physical...
- Head trauma or injury deemed by PI as likely to impact the prefrontal cortex (e.g., loss of consciousness for more than 30 minutes or skull fracture...
- Medical condition or medical treatment that may interfere with the subject's ability to complete the intervention, at discretion of the PI (e.g...
- Inability to sit upright while remaining relatively still and operating a mouse and keypad.
- Current ongoing participation in a research study or participation in a clinical trial and receipt of investigational drug(s) or intervention during...
- Currently prescribed opioid medication for treatment of pain or other disorder (besides opioid use disorder).
See the full eligibility criteria
- Age 18 years to 60 years old.
- Willingness to provide signed, informed consent and commit to completing study procedures
- people must be willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures, and must have access to a cellphone.
- OUD people: Lifetime self-reported history of OUD (according to DSM-5 criteria)
- OUD people: On a stable dose (at least 2 weeks without change) of MOUD (e.g., buprenorphine, methadone) as confirmed by self-report, urine drug screening, and/or the Prescription Drug Monitoring Program database.
- OUD people: Access to a stable residence or space to complete the at-home treatment module
- Current severe psychiatric (e.g., bipolar disorder) or physical (e.g., dementia, Parkinson's disease) determined by self-reported history or physical exam and disorder deemed by PI to significantly interfere with brain...
- Head trauma or injury deemed by PI as likely to impact the prefrontal cortex (e.g., loss of consciousness for more than 30 minutes or skull fracture, intracranial bleeding, or abnormal MRI) as determined by...
- Medical condition or medical treatment that may interfere with the subject's ability to complete the intervention, at discretion of the PI (e.g., extended surgery planned or expecting to give birth during the course of...
- Inability to sit upright while remaining relatively still and operating a mouse and keypad.
- Current ongoing participation in a research study or participation in a clinical trial and receipt of investigational drug(s) or intervention during 30 days prior to the research study, except as explicitly approved by...
- Currently prescribed opioid medication for treatment of pain or other disorder (besides opioid use disorder).
- OUD people: Past 1-year history of non-OUD substance use disorder (other than nicotine, alcohol, or cannabis use disorders).
- OUD people: Positive urine drug screen for any tested substances except for opioids, cocaine, and cannabis at screening or the baseline assessment visit (a test may be repeated if it is needed to confirm accuracy).
- HC people: Lifetime history of any substance use disorder (other than nicotine use disorder at any time and alcohol or cannabis use disorders more than 1 year ago).
- HC people: Positive urine drug screen for any tested substances at screening or the baseline assessment visit (a test may be repeated if it is needed to confirm accuracy).
The study team makes the final eligibility decision.
Where it is enrolling
- Philadelphia, Pennsylvania, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 60 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Philadelphia, Pennsylvania, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.