Systemic Sclerosis study: Sodium Thiosulfate
Official title Intralesional Injection of STS in Treatment of Calcinosis
ClinicalTrials.gov ID: NCT06672822
What this study is testing
What is Sodium Thiosulfate (STS)?
This is an investigational injection being studied to see if it can help with calcium buildup in the skin for people with systemic sclerosis.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study will see if injecting STS into the skin is safe and can lessen calcinosis symptoms and shrink the lesions.
- Who it's for
- Adults who have calcinosis linked to systemic sclerosis, dermatomyositis, or mixed connective tissue disease.
- What's involved
- Participants will receive ultrasound‑guided injections of STS into the affected area and will have their lesion size measured by ultrasound and report their symptoms.
- Time commitment
- The study lasts a few months, with several clinic visits for injections, ultrasound checks, and symptom questionnaires.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Clinical diagnosis of systemic sclerosis, mixed connective tissue disease or inflammatory myopathy
- Must be over 18 years of age
- Participants must be competent to give informed consent
- Participants must have radiographic evidence (xray or ultrasound) of calcinosis.
- Participants must need symptomatic relief
You likely can't join if
- Pregnant women will be excluded
The study team makes the final eligibility decision.
Where it is enrolling
- Pittsburgh, Pennsylvania, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Pittsburgh, Pennsylvania, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.