Gout and Hyperuricemia study: Empagliflozin
Official title SAVE-Care (Sodium Glucose Cotransporter-2 Inhibitors [SGLT2i] As Novel Gout Care) Trial
ClinicalTrials.gov ID: NCT06674109
What this study is testing
What is Empagliflozin 10 mg?
This is an investigational pill being studied to see if it can help lower uric acid levels in people with gout. It is designed to help the kidneys remove extra sugar and uric acid from the blood through the urine.
Also referred to as Jardiance.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing whether empagliflozin lowers uric acid levels. It also checks if it reduces signs of inflammation in the body.
- Who it's for
- You may be able to join if you have gout and high uric acid levels.
- What's involved
- You would take a daily pill. You would get blood tests to check your uric acid and inflammation markers.
- Time commitment
- The study lasts for 3 months and requires regular visits for blood tests.
- Phase 4: studies an already-approved treatment
- Time commitment: about 3 months
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- Provision of signed and dated informed consent form.
- Fulfilling American College of Rheumatology [ACR]/European Alliance of Associations for Rheumatology [EULAR] gout criteria
- 1+ gout flares in last 12 months
- Serum urate level ≥ 6mg/dl
- Males and females; Age 18-80
You likely can't join if
- Estimated Glomerular Filtration Rate [eGFR] \<20ml/min
- Colchicine or nonsteroidal anti-inflammatory drug [NSAID] prophylaxis
- active cardiovascular disease [CVD], type-1 diabetes
- pregnant and lactating women
- Presence of a condition(s) or diagnosis, either physical or psychological, or physical exam finding that precludes participation.
- Use of anti-obesity drugs
See the full eligibility criteria
- Provision of signed and dated informed consent form.
- Fulfilling American College of Rheumatology [ACR]/European Alliance of Associations for Rheumatology [EULAR] gout criteria
- 1+ gout flares in last 12 months
- Serum urate level ≥ 6mg/dl
- Males and females; Age 18-80
- Willingness to adhere to the study intervention procedures.
- Estimated Glomerular Filtration Rate [eGFR] \<20ml/min
- Colchicine or nonsteroidal anti-inflammatory drug [NSAID] prophylaxis
- active cardiovascular disease [CVD], type-1 diabetes
- pregnant and lactating women
- Presence of a condition(s) or diagnosis, either physical or psychological, or physical exam finding that precludes participation. [History of ketoacidosis, end-stage or decompensated liver disease, active cancer]
- Use of anti-obesity drugs
- Basal-bolus or multiple daily injection insulin regimens, or loop diuretics
The study team makes the final eligibility decision.
Where it is enrolling
- Boston, Massachusetts, United States
Compensation & support
A stipend or payment for your time may be offered.
No amount is published here because ClinicalTrials.gov has no reliable field for payment or travel support. Ask the study team what's actually covered (payment for your time, travel, parking, or other study costs), and never join a trial for the compensation alone.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team, so confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The study runs about 3 months per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Boston, Massachusetts, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.