Clinical trial for Ulcerative Colitis (UC)
Official title STOP-UC: De-escalation of Therapy in Patients With Ulcerative Colitis With Histological Remission
ClinicalTrials.gov ID: NCT06693310
What this study is testing
- What it's testing
- This study aims to find out if keeping the disease under control is possible when patients lower or stop their treatment.
- Who it's for
- People with ulcerative colitis whose disease is currently inactive and shows no signs of inflammation.
- What's involved
- Participants will either continue their current medicine or reduce/stop it, and provide blood, stool, and tissue samples for testing.
- Time commitment
- The study involves regular medical care and sample collection, but the specific duration is not listed.
Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 75
You may be able to join if
- Consenting patients aged 18 to 75 years with an established diagnosis of ulcerative colitis (UC) for at least 3 years.
- Patients in deep remission, defined by the absence of endoscopic and histologic signs of active inflammation (i.e.
- If the most recent colonoscopy is within the last 3 years and demonstrates normalized/quiescent pathology findings (i.e., patient is in stable...
- Patients in clinical, biochemical (fecal calprotectin \<100), radiologic and endoscopic remission since the last colonoscopy.
You likely can't join if
- Any noted active inflammation [clinical, sonographic, biochemical, endoscopic (in any colonic segment)].
- Patients with any changes in therapy after colonoscopy showing histological normalization or quiescence.
- Corticosteroid use after colonoscopy showing histologic normalization or quiescence.
- Patients with any noted history of primary sclerosing cholangitis or invisible or unresected high-grade dysplasia (suspected or confirmed).
- Pregnancy or actively trying to conceive
- Inability to follow the proposed sample collection and monitoring protocol.
The study team makes the final eligibility decision.
Where it is enrolling
- Chicago, Illinois, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Chicago, Illinois, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.