Clinical trial for Major Depressive Disorder (MDD)
Official title Cognitive Rehabilitation for Veterans With MDD-related Cognitive Functioning Deficits
ClinicalTrials.gov ID: NCT06728774
What this study is testing
- What it's testing
- The study checks if the training is doable and liked by veterans, and looks at early signs of improvement in thinking, mood, daily life and quality of life.
- Who it's for
- Veterans who had depression treatment in the past year and still have memory or attention difficulties.
- What's involved
- Participants will do a 2‑hour baseline test of memory, attention and mood, then join weekly 2‑hour group sessions for 8 weeks. They will be randomly assigned to either the brain‑training program or a goal‑setting support group, and will finish with a 2‑hour follow‑up test and interview.
- Time commitment
- The study lasts 8 weeks, with a 2‑hour assessment at the start, weekly 2‑hour group meetings for 8 weeks, and a 2‑hour assessment at the end.
Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Veterans 18 years of age or older
- Self-reported concerns about cognitive functioning deficits or clinical concerns about cognitive functioning deficits documented in EHR
- meets DSM-5 criteria for MDD and receiving treatment for this diagnosis at the Portland VA within the past year
- moderate or greater depressive symptoms as assessed by a PHQ-9 score ≥ 10
- current cognitive functioning deficits as determined by performance on at least two measures in one cognitive domain (i.e., memory...
You likely can't join if
- impaired capacity to understand study risks and benefits
- history of TBI as defined by American College of Rehabilitation Medicine and VA/DoD criteria
- meets DSM-5 criteria for a substance use disorder other than nicotine use disorder in the past 6 months
- meets DSM-5 criteria for dementia, psychotic disorder, or "with psychotic features" specifier
- active suicidal intent with significant clinical risk
- auditory or visual impairments that would prevent ability to participate in cognitive rehabilitation group or assessments.
The study team makes the final eligibility decision.
Where it is enrolling
- Portland, Oregon, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Portland, Oregon, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.