Alcohol Use Disorder study: Kenetik
Official title Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder
ClinicalTrials.gov ID: NCT06807918
What this study is testing
- What it's testing
- This study aims to see if a nutritional ketone supplement affects how the brain works and how much alcohol people want to drink.
- Who it's for
- The study is looking for adults who have alcohol use disorder.
- What's involved
- Participants will take two brain scans and drink a specific amount of alcohol in a lab setting. They will receive the ketone drink on one visit and a fake drink (placebo) on the other.
- Time commitment
- The study involves two lab visits where participants undergo brain scans and alcohol testing.
- Phase 3: a large, late-stage study
You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 21 to 65
You may be able to join if
- Age 21-65 years old
- Able to provide written informed consent
- Meets current DSM-5 criteria for mild to moderate (established using MINI)
- Average weekly alcohol consumption of at least 15 standard drinks over the past month before consent (self-report)
- Not seeking treatment for AUD (self-report)
You likely can't join if
- Unwilling or unable to refrain from use of alcohol, within 24 hours of Alcohol Bar Lab, MRI and PET procedures (self-report, breathalyzer).
- Use of psychoactive medications or medications that may affect study results (self-report, medical history).
- Current DSM-5 diagnosis of a major psychiatric disorder (other than alcohol, Marijuana, and nicotine use disorders) that required hospitalization or...
- Current significant alcohol withdrawal symptoms in the past 12 months that required medical treatment (self-report, medical history).
- A current, clinically significant physical disease or abnormality on the basis of medical history, physical examination, or routine laboratory...
- Current, major gastrointestinal (GI) diseases, such as: GERD, Crohn's disease, Irritable bowel syndrome, Ulcerative colitis, Celiac disease...
See the full eligibility criteria
- Age 21-65 years old
- Able to provide written informed consent
- Meets current DSM-5 criteria for mild to moderate (established using MINI)
- Average weekly alcohol consumption of at least 15 standard drinks over the past month before consent (self-report)
- Not seeking treatment for AUD (self-report)
- Unwilling or unable to refrain from use of alcohol, within 24 hours of Alcohol Bar Lab, MRI and PET procedures (self-report, breathalyzer).
- Use of psychoactive medications or medications that may affect study results (self-report, medical history).
- Current DSM-5 diagnosis of a major psychiatric disorder (other than alcohol, Marijuana, and nicotine use disorders) that required hospitalization or daily medication in the past year.
- Current significant alcohol withdrawal symptoms in the past 12 months that required medical treatment (self-report, medical history).
- A current, clinically significant physical disease or abnormality on the basis of medical history, physical examination, or routine laboratory evaluation that could interfere with study participation or make it...
- Current, major gastrointestinal (GI) diseases, such as: GERD, Crohn's disease, Irritable bowel syndrome, Ulcerative colitis, Celiac disease Diverticulitis, or other clinically significant physical disease that may...
- Clinically significant laboratory findings that could affect brain function (e.g., HIV+).
- Head trauma with loss of consciousness for more than 30 minutes (self-report, medical history).
- Pregnant or breast-feeding
- Weight greater than 250lbs (Need to cap amount of alcohol give based on weight to individuals).
- BMI greater than 35.
- Self-reported claustrophobia.
- Contraindications to MRI (e.g., metal in the body that cannot be removed and is not MRI compatible).
The study team makes the final eligibility decision.
Where it is enrolling
- Philadelphia, Pennsylvania, United States
Compensation & support
A stipend or payment for your time may be offered.
No amount is published here because ClinicalTrials.gov has no reliable field for payment or travel support. Ask the study team what's actually covered (payment for your time, travel, parking, or other study costs), and never join a trial for the compensation alone.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team, so confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 21 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Philadelphia, Pennsylvania, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.