Clinical trial for Chronic Pain Patients
Official title Medical Cannabis and Behavior
ClinicalTrials.gov ID: NCT06808048
What this study is testing
- What it's testing
- This study is testing whether different types of medical cannabis change how well you think and how your brain works. It also looks at how age and blood levels of cannabis chemicals might affect these changes.
- Who it's for
- You may be able to join if you are an adult with chronic pain who uses medical cannabis and can visit a local dispensary for the study.
- What's involved
- You will start with a baseline check before you begin using cannabis. Then you will have monthly phone calls to talk about how you are using the medicine. After four months you will have a final check to see how your thinking and brain have changed.
- Time commitment
- The study lasts about four months and includes one baseline visit, monthly phone calls, and one final visit.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 30 to 75
You may be able to join if
- Medical cannabis users (n=120) will be required to
- Be ages 30-75;
- Be qualified for a medical cannabis prescription based only on a diagnosis of chronic pain
- Have normal or corrected-to-normal vision and hearing;
- Be free of current and past DSM-V-defined substance use disorders; have \< 5 lifetime recreational uses of illicit drugs.
You likely can't join if
- Cannot have a degenerative neurological condition or a neurological condition that impacts brain function (e.g., epilepsy);
- No contraindications to MRI scanning;
- No lifetime history of severe DSM-V psychopathology (psychotic disorders, bipolar disorder)
- No current pregnancy or pregnancy within the prior 3 months; cannot be lactating;
See the full eligibility criteria
- Medical cannabis users (n=120) will be required to
- Be ages 30-75;
- Be qualified for a medical cannabis prescription based only on a diagnosis of chronic pain; note that individuals can, in theory, utilize medical cannabis for more than one qualifying condition.
- Have normal or corrected-to-normal vision and hearing;
- Be free of current and past DSM-V-defined substance use disorders; have \< 5 lifetime recreational uses of illicit drugs.
- Have limited daily exposure to nicotine (e.g., no daily smokers/vapers; use of nicotine products fewer than 5 occasions weekly);
- Willing to abstain from alcohol, nicotine, and other (non-treatment) drugs for 24 hours prior to study. Abstinence will be verified by breathalyzer and urine drug screening
- Must be right handed as assessed by the Edinburgh Handedness Inventory;
- No history of daily cannabis use; limited cannabis product use (recreational or therapeutic) within the past three months;
- Able to schedule and complete a multi-hour single session protocol;
- Have sufficient manual mobility to be able to complete computerized neurocognitive assessments;
- Be ages 30-75;
- Suffer from a chronic pain condition that could qualify them for medical cannabis; People with orthopedic pain will be prioritized.
- Have normal or corrected-to-normal vision and hearing;
- Be free of current and past DSM-V-defined substance use disorders; have \< 5 lifetime recreational uses of illicit drugs.
- Have limited daily exposure to nicotine (e.g., no daily smokers/vapers; use of nicotine products fewer than 5 occasions weekly);
- Willing to abstain from alcohol, nicotine, and other (non-treatment) drugs for 24 hours prior to study. Abstinence will be verified by breathalyzer and urine drug screening
- Must be right handed as assessed by the Edinburgh Handedness Inventory;
- No history of daily cannabis use; cannabis use within the past three months limited to a few times.
- Able to schedule and complete a multi-hour single session protocol;
- Have sufficient manual mobility to be able to complete computerized neurocognitive assessments;
- Able to communicate with the researchers by phone during the four month pre-post assessment interval Within both groups, concomitant opioid use will be allowed as will other prescribed treatments.
- Cannot have a degenerative neurological condition or a neurological condition that impacts brain function (e.g., epilepsy);
- No contraindications to MRI scanning;
- No lifetime history of severe DSM-V psychopathology (psychotic disorders, bipolar disorder); if currently treated mood for anxiety disorders, must be stable;
- No current pregnancy or pregnancy within the prior 3 months; cannot be lactating;
The study team makes the final eligibility decision.
Where it is enrolling
- Minneapolis, Minnesota, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 30 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Minneapolis, Minnesota, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.