Chronic Migraine study: Atogepant
Official title A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years
ClinicalTrials.gov ID: NCT06810505
What this study is testing
What is Atogepant?
An investigational oral tablet being studied as a preventive treatment for chronic migraine in patients aged 12 to 17 years. It is designed to block the calcitonin gene‑related peptide (CGRP) receptor, which is involved in migraine pathways.
Also referred to as Qulipta, Aquipta.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing whether atogepant can prevent chronic migraine in people aged 12 to 17.
- Who it's for
- You may be able to join if you are 12 to 17 years old and have chronic migraine.
- What's involved
- You will take one tablet each day for 12 weeks. You will visit the clinic, fill a daily diary, have check‑ups and blood tests.
- Time commitment
- The study lasts about 16 weeks with visits during the 12‑week treatment and a 4‑week follow‑up.
- Phase 3: a large, late-stage study
- You might receive a placebo (an inactive treatment) instead of the study drug. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 12 to 17
You may be able to join if
- History of chronic migraine with or without aura consistent with a diagnosis according to the International Classification of Headache Disorders, 3rd...
- Participant must have completed the eDiary for a minimum of 20 out of 28 days.
- Participant has \>= 15 headache days.
- Participant has \>= 8 migraine days.
You likely can't join if
- Clinically significant hypertension per investigator's judgment.
- History of any clinically significant hematologic, endocrine, pulmonary, renal, hepatic, gastrointestinal, cardiovascular or neurologic disease.
The study team makes the final eligibility decision.
Where it is enrolling
- Huntsville, Alabama, United States
- Little Rock, Arkansas, United States
- Anaheim, California, United States
- Fresno, California, United States
- Long Beach, California, United States
- Oceanside, California, United States
- San Jose, California, United States
- Walnut Creek, California, United States
- Gulf Breeze, Florida, United States
- Miami, Florida, United States
- Weston, Florida, United States
- Winter Park, Florida, United States
- Evansville, Indiana, United States
- Ann Arbor, Michigan, United States
- Ridgeland, Mississippi, United States
- Papillion, Nebraska, United States
- Nashua, New Hampshire, United States
- Amherst, New York, United States
- Philadelphia, Pennsylvania, United States
- Scottdale, Pennsylvania, United States
+ 40 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 12 years to 17 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Huntsville, Alabama, United States; Little Rock, Arkansas, United States; Anaheim, California, United States; Fresno, California, United States; Long Beach, California, United States; Oceanside, California, United States and 54 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.