COPD study: Bronchodilators inhalation
Official title Bronchodilators and Lung Mechanics During Exercise in COPD
ClinicalTrials.gov ID: NCT06825013
What this study is testing
What is Bronchodilators inhalation?
This is an investigational inhaled medicine being studied to see if it helps people with COPD breathe better during exercise. It is designed to open the airways in the lungs to help air move more easily.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study wants to see if the bronchodilator lowers resistance in the small airways and reduces breathlessness during exercise.
- Who it's for
- Adults who have COPD and can exercise in a lab setting.
- What's involved
- Participants will visit the lab three times. Two of those visits will be identical, one with the bronchodilator and one with a placebo, while lung function and exercise tests are done.
- Time commitment
- The study lasts about a week, with three lab visits and two drug/placebo sessions during the second and third visits.
- Phase 4: studies an already-approved treatment
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 and older
You may be able to join if
- Diagnosis of COPD
- Male or female ≥40-years-of-age
- Current or former smokers with ≥20 pack-year history
- Forced expiratory volume in 1 second (FEV1)/ forced vital capacity (FVC)\<lower limit of normal
- Pre-Post Change of FVC ≥ 10% predicted after 400 mcg inhaled salbutamol
You likely can't join if
- Major cardiopulmonary diseases other than COPD (asthma, interstitial lung disease, pulmonary hypertension, and congestive heart failure)
- Neuromuscular or musculoskeletal disease
- Use of daytime oxygen or exercise induced O2 desaturation to \< 80% on room air;
- Any other disorder that may contribute to exertional dyspnoea and/or exercise intolerance
- Any contraindication to cardiopulmonary exercise testing
See the full eligibility criteria
- Diagnosis of COPD
- Male or female ≥40-years-of-age
- Current or former smokers with ≥20 pack-year history
- Forced expiratory volume in 1 second (FEV1)/ forced vital capacity (FVC)\<lower limit of normal
- Pre-Post Change of FVC ≥ 10% predicted after 400 mcg inhaled salbutamol
- Functional residual capacity ≥120%predicted and/or the upper limit of normal
- Modified Medical Research Council dyspnea scale ≥ 2
- Clinically stable as defined by no exacerbations in the preceding 6 weeks
- Ability to provide informed consent and perform all study procedures
- Major cardiopulmonary diseases other than COPD (asthma, interstitial lung disease, pulmonary hypertension, and congestive heart failure)
- Neuromuscular or musculoskeletal disease
- Use of daytime oxygen or exercise induced O2 desaturation to \< 80% on room air;
- Any other disorder that may contribute to exertional dyspnoea and/or exercise intolerance
- Any contraindication to cardiopulmonary exercise testing
The study team makes the final eligibility decision.
Where it is enrolling
- Kingston, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Kingston, Ontario, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.