Preterm Birth study: Daily aspirin vs Split dose aspirin
Official title Daily Aspirin vs Split Dosing in High-risk Pregnancies (DASH)
ClinicalTrials.gov ID: NCT06826859
What this study is testing
What is Daily aspirin (ASA)?
An investigational daily aspirin dose being studied to reduce the risk of preterm birth in high‑risk pregnancies.
Also referred to as aspirin.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study wants to find out if taking aspirin once a day or twice a day changes how well it works in preventing preeclampsia and preterm birth. It also looks at how pregnancy affects aspirin’s action and whether certain markers predict outcomes.
- Who it's for
- Pregnant people who are at high risk for preeclampsia or preterm birth and are already advised to take aspirin
- What's involved
- Participants will be randomly assigned to take either 162 mg of aspirin once a day or 81 mg twice a day. They will have regular visits and tests to measure aspirin response and pregnancy outcomes.
- Time commitment
- The study lasts until delivery, with several clinic visits and blood tests scheduled during pregnancy.
- Phase 2: a mid-size study of how well it works
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 16 to 55, women only
You may be able to join if
- Singleton gestation gestational age \<16 0/7 weeks, dating confirmed with ultrasound
- ≥1 high risk factor for preeclampsia or ≥2 moderate risk factors as per United States Preventative Services Task Force (2021)
- Recommendation for 162mg aspirin daily in pregnancy
- Age 16-55 years old
You likely can't join if
- Contraindication to aspirin
- Current or planned use of any other anticoagulation
- Thrombocytopenia, other known platelet or bleeding disorder
- Abnormally elevated baseline PFA-100 epinephrine closure time prior to aspirin initiation
The study team makes the final eligibility decision.
Where it is enrolling
- Philadelphia, Pennsylvania, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 16 years to 55 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Philadelphia, Pennsylvania, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.