Chronic Kidney Disease study: NSAIDs
Official title Safety of Short-course of NSAIDs in Pediatric Patients With CKD
ClinicalTrials.gov ID: NCT06860711
What this study is testing
What is NSAIDs?
Investigational use of NSAIDs in the postoperative setting to study the risk of acute kidney injury in pediatric patients with mild-to-moderate chronic kidney disease. NSAIDs are designed to reduce inflammation and pain by inhibiting cyclooxygenase enzymes.
Also referred to as ketorolac, ibuprofen.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study wants to find out whether giving NSAIDs after surgery increases the chance of acute kidney injury in these children.
- Who it's for
- Children with mild‑to‑moderate chronic kidney disease who are having urologic surgery.
- What's involved
- Kids will receive a short course of NSAIDs after their operation and will have kidney function checked through lab tests and doctor visits.
- Time commitment
- The study follows participants for a few weeks after surgery, with several follow‑up visits and tests.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 25
You may be able to join if
- Patients over 18 months of age
- diagnosis of CKD stages 2-3a, confirmed by CKiD U25 eGFR calculator based on cystatin C laboratory testing within 6 months of surgery
- Patient is scheduled to undergo a urologic surgery requiring admission or overnight stay in the hospital
You likely can't join if
- Diagnosis of CKD stage 1 or 4-5
- Past medical history of renal transplant
- Past medical history of nasal polyp
- Procedure for oncologic indications or on chemotherapy
- Pregnant patient
- True allergy to NSAIDs
The study team makes the final eligibility decision.
Where it is enrolling
- Aurora, Colorado, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 months to 25 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Aurora, Colorado, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.