Clinical trial for Essential Tremor
Official title Attention and Eye Movement in Parkinson's Disease
ClinicalTrials.gov ID: NCT06899022
What this study is testing
- What it's testing
- This study is testing whether deep brain stimulation improves or worsens attention and how people see facial emotions. It also looks at how the brain parts targeted by the device help control attention.
- Who it's for
- You may be able to join if you have Parkinson’s disease, essential tremor, or dystonia and are considering deep brain stimulation.
- What's involved
- You will look at pictures of faces on a computer and rate their emotions. You will do this before the surgery, while the electrodes are being placed, and after the treatment starts. A camera will track where you look on the screen.
- Time commitment
- The study lasts about one hour for each session, with three sessions: before surgery, during surgery, and after treatment starts.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 19 to 90. Healthy volunteers may be eligible.
You may be able to join if
- Ability and willingness to provide signed informed consent for this study
- Ability to express perceptual judgments through a button press or mouse- controlled computerized slider
- Age 19 - 90 years
- Diagnosis of idiopathic Parkinson's disease (PD), essential tremor (ET) or dystonia (DT).
- Scheduled for new implantation of a therapeutic DBS device targeted to subthalamic nucleus (STN), ventral intermediate nucleus of thalamus (VIM) or...
You likely can't join if
- Corrected visual acuity insufficient to perceptually judge face stimuli
- Inability to understand task instructions or complete task requirements
- DBS Participants (Aim 1): o Insufficient therapeutic control of motor symptoms to engage in tasks requiring button press or use of a mouse to control...
- Healthy Comparison Participants (Aim 1): o History of neurodegenerative disorder
- Corrected visual acuity insufficient to perceptually judge face stimuli
- Inability to understand task instructions or complete task requirements
See the full eligibility criteria
- Ability and willingness to provide signed informed consent for this study
- Ability to express perceptual judgments through a button press or mouse- controlled computerized slider
- Age 19 - 90 years
- Diagnosis of idiopathic Parkinson's disease (PD), essential tremor (ET) or dystonia (DT).
- Scheduled for new implantation of a therapeutic DBS device targeted to subthalamic nucleus (STN), ventral intermediate nucleus of thalamus (VIM) or internal globus pallidus (GPi)
- Comparison Participants (Aim 1): o Selection by age matching to participants in PD group
- Ability and willingness to provide signed informed consent for this study
- Ability to express perceptual judgments through a button press or mouse- controlled computerized slider
- Age 19 - 90 years
- Scheduled for awake DBS implantation with clinical micro-electrode recordings (MER)
- Willing and able to engage in tasks during an awake surgical procedure
- Ability and willingness to provide signed informed consent for this study
- Ability to express perceptual judgments through a button press or mouse- controlled computerized slider
- Age 19 - 90 years
- Willing to undergo acute manipulations of DBS
- Able to tolerate acute changes of DBS
- Corrected visual acuity insufficient to perceptually judge face stimuli
- Inability to understand task instructions or complete task requirements
- DBS Participants (Aim 1): o Insufficient therapeutic control of motor symptoms to engage in tasks requiring button press or use of a mouse to control a slider
- Healthy Comparison Participants (Aim 1): o History of neurodegenerative disorder
- Corrected visual acuity insufficient to perceptually judge face stimuli
- Inability to understand task instructions or complete task requirements
- Not undergoing awake DBS implantation
- Uncorrected visual acuity insufficient to perceptually judge face stimuli
- Corrected visual acuity insufficient to perceptually judge face stimuli
- Inability to understand task instructions or complete task requirements
- Failure of DBS to achieve a therapeutic effect on motor symptoms
The study team makes the final eligibility decision.
Where it is enrolling
- Omaha, Nebraska, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 19 years to 90 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Omaha, Nebraska, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.