OSA - Obstructive Sleep Apnea study: Eszopiclone vs Lemborexant
Official title Effects of Eszopiclone and Lemborexant in People With OSA With a Low Arousal Threshold Who Have Difficulty Sleeping
ClinicalTrials.gov ID: NCT06928766
What this study is testing
What is Eszopiclone 3 mg?
This is an investigational medicine being studied to help people with obstructive sleep apnea and trouble staying asleep. It is designed to help the brain relax and make it harder to wake up during minor breathing pauses.
Also referred to as Lunesta.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study wants to find out if combining two specific types of sleep medicine can help people with sleep apnea stay asleep longer by making them less likely to wake up from minor breathing pauses.
- Who it's for
- The study is looking for adults who have obstructive sleep apnea, have a low threshold for waking up (meaning they wake up easily), and have trouble falling or staying asleep.
- What's involved
- Participants will take either a placebo (sugar pill) or the study medicines. They will spend two nights in a sleep lab where their sleep, breathing, and next-day performance will be monitored.
- Time commitment
- The study involves two overnight stays in a sleep lab to compare the effects of the treatments.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Moderate or more difficulty "staying or initiating asleep" score on the Insomnia Severity Index questionnaire
- Obstructive Sleep Apnoea (OSA), Apnoea Hypopnea Index ≥ 10 events/hour
- Low arousal respiratory threshold OSA endotype
- BMI ≤35 kg/m2
You likely can't join if
- Concomitant medications that interact or are contraindicated with eszopiclone, zopiclone, and Lemborexant
- Concomitant medications known to influence breathing, sleep, arousal, or muscle physiology
- Current pregnancy or breast-feeding
- Current or recent other medical conditions likely to affect results or safety
The study team makes the final eligibility decision.
Where it is enrolling
- Bedford Park, South Australia, Australia
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Bedford Park, South Australia, Australia. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.