Clinical trial for Obsessive Compulsive Disorder (OCD)
Official title Brain-Oscillation Synchronized Stimulation of the DMPFC
ClinicalTrials.gov ID: NCT06942559
What this study is testing
- What it's testing
- This study wants to see if a personalized form of brain stimulation works better than standard treatment for obsessive-compulsive disorder. It also looks at how the brain changes during the treatment.
- Who it's for
- The study is looking for adults with obsessive-compulsive disorder that has not responded well to other treatments.
- What's involved
- Participants will receive magnetic pulses to a specific part of the brain. Some will get a personalized version that uses brain wave readings to time the pulses, while others get the standard version.
- Time commitment
- The source text does not specify the total duration or the number of visits required.
Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- Are 18-65 years old;
- Have OCD as a primary disorder, confirmed by a MINI diagnosis of OCD;
- Have OCD with treatment resistance as defined by failure of at least a course of cognitive-behavioural therapy or a single trial (≥4 weeks) of an...
- Does not meet criteria for substance use disorder as determined by the MINI (with the exception of nicotine and caffeine);
- Have a Y-BOCS score ≥20;
You likely can't join if
- Have any contraindications to TMS as determined by the TASS questionnaire (18);
- Have a history of a medical or neurological disorder that affects CNS (such as, traumatic brain injury, stroke, Parkinson);
- Are pregnant or breast feeding. TMS is not unsafe in pregnancy and therefore we are not requiring a pregnancy test prior to entry.
- Have history of seizures;
- Have any metal implant or dentures;
- Have serious or unstable medical condition requiring immediate investigation or treatment (e.g. severe or recent cardiac disease);
See the full eligibility criteria
- Are 18-65 years old;
- Have OCD as a primary disorder, confirmed by a MINI diagnosis of OCD;
- Have OCD with treatment resistance as defined by failure of at least a course of cognitive-behavioural therapy or a single trial (≥4 weeks) of an SSRI;
- Does not meet criteria for substance use disorder as determined by the MINI (with the exception of nicotine and caffeine);
- Have a Y-BOCS score ≥20;
- Are fluent in the English language (spoken, written and reading);
- Have had no increase or initiation of any psychotropic medication in the 4 weeks prior to screening;
- Must be deemed to have capacity to provide informed consent;
- Must sign and date the informed consent form;
- Stated willingness to comply with all study procedures.
- Have any contraindications to TMS as determined by the TASS questionnaire (18);
- Have a history of a medical or neurological disorder that affects CNS (such as, traumatic brain injury, stroke, Parkinson);
- Are pregnant or breast feeding. TMS is not unsafe in pregnancy and therefore we are not requiring a pregnancy test prior to entry. If patients become pregnant during the study they will not be excluded.
- Have history of seizures;
- Have any metal implant or dentures;
- Have serious or unstable medical condition requiring immediate investigation or treatment (e.g. severe or recent cardiac disease);
- Have cardiac pacemaker, cochlear implants, implanted electronic devices or non- electronic metallic implants or other contraindications for TMS;
- Taking more than 2mg of lorazepam or equivalent benzodiazepine, or any anticonvulsant medication;
- Fulfill MINI criteria for Alcohol Use Disorder;
- Have received any ablative neurological procedure (e.g., focused ultrasound).
The study team makes the final eligibility decision.
Where it is enrolling
- Toronto, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Toronto, Ontario, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.