Heart Failure study: Rubidium-82
Official title 18F-mFBG Imaging for Myocardial Sympathetic Innervation
ClinicalTrials.gov ID: NCT06965621
What this study is testing
What is 18F-metaFluorobenzylguanidine (IRP101)?
An investigational PET radiopharmaceutical being studied to assess myocardial sympathetic innervation in heart failure patients. It is designed to bind to cardiac sympathetic nerve endings and emit positrons that can be detected by PET imaging.
Also referred to as IRP101.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study aims to see how well 18F-mFBG shows heart sympathetic nerves, compare its results to older imaging agents, and explore differences in patients who have or have not had an ICD shock in the past year.
- Who it's for
- Stable adults with heart failure from ischemic cardiomyopathy, left‑ventricular ejection fraction 35% or less, and an implanted cardioverter‑defibrillator.
- What's involved
- Participants receive a single injection of the 18F-mFBG tracer and undergo PET imaging of the heart, along with standard perfusion PET scans; safety checks are performed for any adverse events.
- Time commitment
- One imaging visit (including the tracer injection and scans) with short follow‑up safety monitoring.
- Phase 2: a mid-size study of how well it works
- Time commitment: about 4 years
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Stable heart failure from ischemic cardiomyopathy, LVEF \< or = 35%, ICD implantation for at least 12 months
You likely can't join if
- Unstable coronary artery disease, no ICD implantation
The study team makes the final eligibility decision.
Where it is enrolling
- Houston, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The study runs about 4 years per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Houston, Texas, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.