Clinical trial for Parkinson Disease
Official title Slow-SPEED: Slowing Parkinson's Early Through Exercise Dosage
ClinicalTrials.gov ID: NCT06993142
What this study is testing
- What it's testing
- The study wants to see if a remote app can increase daily steps and exercise time in people with LRRK2 G2019S or GBA1 N370S mutations, and whether that exercise changes early Parkinson markers.
- Who it's for
- It looks for adults who carry the LRRK2 G2019S or GBA1 N370S genetic mutations linked to Parkinson’s disease.
- What's involved
- Participants will use a special Slow Speed app to track and boost their daily steps and heart‑rate‑based exercise minutes. They will also have digital health checks to monitor Parkinson‑related symptoms.
- Time commitment
- The study lasts 24 months, with ongoing app use and regular remote digital assessments throughout that period.
Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 and older
You may be able to join if
- previously identified LRRK2 G2019S or GBA N370S variant based on genotyping
- aged 50 years or older
- able to understand the English language
- being able to walk independently inside the home without the use of a walking aid
- in possession of a suitable smartphone (screen size minimum 4.6 inch), (Android version 9 or iOS version 15 or newer)
You likely can't join if
- clinically diagnosed or self-reported diagnosis neurodegenerative disease
- self-reported falls of three or more per year
- dexterity problems or cognitive impairments hampering smartphone use
- if they are not aware of and do not wish to be informed about an increased risk of developing diseases associated with the LRRK2 or GBA1 risk variant
- if individual is not community-dwelling
- in possession of one of the following devices: Huawei P8 Lite; Huawei P9 Lite; Xiaomi Mi 6; Huawei P20 Lite (Fitbit is incompatible)
See the full eligibility criteria
- previously identified LRRK2 G2019S or GBA N370S variant based on genotyping
- aged 50 years or older
- able to understand the English language
- being able to walk independently inside the home without the use of a walking aid
- in possession of a suitable smartphone (screen size minimum 4.6 inch), (Android version 9 or iOS version 15 or newer)
- Not in a high physical activity range during the 4-week eligibility and baseline period
- clinically diagnosed or self-reported diagnosis neurodegenerative disease
- self-reported falls of three or more per year
- dexterity problems or cognitive impairments hampering smartphone use
- if they are not aware of and do not wish to be informed about an increased risk of developing diseases associated with the LRRK2 or GBA1 risk variant
- if individual is not community-dwelling
- in possession of one of the following devices: Huawei P8 Lite; Huawei P9 Lite; Xiaomi Mi 6; Huawei P20 Lite (Fitbit is incompatible)
The study team makes the final eligibility decision.
Where it is enrolling
- Rochester, New York, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 50 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Rochester, New York, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.