Clinical trial for Tabacco Use Disorder
Official title Personalized Brain Stimulation to Help Veterans Quit Smoking
ClinicalTrials.gov ID: NCT07050862
What this study is testing
- What it's testing
- The study will compare standard repetitive transcranial magnetic stimulation (rTMS) with a precision‑targeted rTMS to see which is more effective for quitting cigarettes.
- Who it's for
- Veterans who currently smoke cigarettes.
- What's involved
- Participants will receive a series of non‑invasive brain‑stimulation sessions and will complete questionnaires and health checks during the study.
Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70
You may be able to join if
- Veteran
- Individuals who smoke 10 or more cigarettes per day and have a CO level \> 10 ppm indicative of recent smoking
- Those who have not received substance abuse treatment within the previous 30 days
- Those who have been stable on psychotropic medications for at least three months
- For females, those who test non-pregnant and use adequate birth control
You likely can't join if
- Current moderate to severe substance use of any psychoactive substances other than nicotine or caffeine, as defined by DSM-V criteria
- Contraindications to MRI (e.g., metal in the skull, orbital or intracranial cavity, or claustrophobia)
- Contraindications to rTMS (history of a seizure or epilepsy)
- A history of autoimmune, endocrine, viral, or vascular disorders affecting the brain
- History or MRI evidence of neurological disorder that would lead to local or diffuse brain lesions or significant physical impairment
- Unstable cardiac disease, uncontrolled hypertension, severe renal or liver insufficiency, or sleep apnea
See the full eligibility criteria
- Veteran
- Individuals who smoke 10 or more cigarettes per day and have a CO level \> 10 ppm indicative of recent smoking
- Those who have not received substance abuse treatment within the previous 30 days
- Those who have been stable on psychotropic medications for at least three months
- For females, those who test non-pregnant and use adequate birth control
- Those who are willing to provide informed consent
- Those who can comply with protocol requirements and likely complete all study procedures
- Those who are motivated to quit smoking (based on responses of "very likely" or "somewhat likely" in the motivation questionnaire
- Current moderate to severe substance use of any psychoactive substances other than nicotine or caffeine, as defined by DSM-V criteria
- Contraindications to MRI (e.g., metal in the skull, orbital or intracranial cavity, or claustrophobia)
- Contraindications to rTMS (history of a seizure or epilepsy)
- A history of autoimmune, endocrine, viral, or vascular disorders affecting the brain
- History or MRI evidence of neurological disorder that would lead to local or diffuse brain lesions or significant physical impairment
- Unstable cardiac disease, uncontrolled hypertension, severe renal or liver insufficiency, or sleep apnea
- Major Axis I disorders diagnosed according to DSM-V criteria, such as bipolar affective disorder, schizophrenia, dementia, or major depression
- Regarding the Veteran population, the investigators will enroll smokers who have PTSD
- Current use of other forms of nicotine delivery, such as nicotine patches or electronic cigarettes
- Currently prescribed bupropion and/or varenicline
The study team makes the final eligibility decision.
Where it is enrolling
- Charleston, South Carolina, United States
Compensation & support
This study's listing mentions compensation or reimbursement.
No amount is published here because ClinicalTrials.gov has no reliable field for payment or travel support. Ask the study team what's actually covered (payment for your time, travel, parking, or other study costs), and never join a trial for the compensation alone.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team, so confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Charleston, South Carolina, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.