Osteoarthritis (OA) of the Knee study: Metformin
Official title Anti-Diabetic Drug, Exercise and Healthy Diet for Knee Osteoarthritis With Overweight/Obesity
ClinicalTrials.gov ID: NCT07065591
What this study is testing
What is Metformin?
An investigational oral medication being studied as a potential treatment for knee osteoarthritis. It is designed to improve insulin sensitivity and reduce body weight, which may lessen stress on the knee joint.
Also referred to as Metfomin.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study wants to find out if a combination of diet changes, exercise, and the diabetes drug metformin can reduce knee pain, lower body weight, and improve symptoms in people with knee osteoarthritis.
- Who it's for
- Adults who are overweight or obese and have knee osteoarthritis.
- What's involved
- Participants will follow a specific diet, do regular exercise, and take metformin tablets. They will also have regular check‑ups and measurements of pain and weight.
- Time commitment
- The study lasts several months with periodic clinic visits for assessments and medication refills.
- Phase 1: an early, usually small safety study
- Time commitment: about 6 months
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 to 80
You may be able to join if
- Men and women age between 40 and 80 years old, with overweight or obesity (body mass index ≥23 kg/m2) according to Hong Kong Centre for Health...
- Knee pain for 6+ months with Visual Analogue Scale (VAS) \> 40mm/100mm and
- Meet the American College of Rheumatology criteria for knee OA
- OA referred for consideration for joint replacement
You likely can't join if
- Severe radiographic knee OA (Kellgren-Lawrence grade 4) or severe knee pain (VAS\>80mm/100 mm) that could not tolerate further conservative...
- inflammatory arthritis like rheumatoid arthritis, crystal arthritis, etc.
- Preexisting diabetes on antidiabetic drug or drug allergy to metformin.
- Recent knee surgery of the same knee
- Significant bone loss.
- Concomitant neuromuscular diseases affecting lower limb function.
See the full eligibility criteria
- Men and women age between 40 and 80 years old, with overweight or obesity (body mass index ≥23 kg/m2) according to Hong Kong Centre for Health Protection definition of overweight and obesity.
- Knee pain for 6+ months with Visual Analogue Scale (VAS) \> 40mm/100mm and
- Meet the American College of Rheumatology criteria for knee OA
- OA referred for consideration for joint replacement
- Severe radiographic knee OA (Kellgren-Lawrence grade 4) or severe knee pain (VAS\>80mm/100 mm) that could not tolerate further conservative management;
- inflammatory arthritis like rheumatoid arthritis, crystal arthritis, etc.
- Preexisting diabetes on antidiabetic drug or drug allergy to metformin.
- Recent knee surgery of the same knee
- Significant bone loss.
- Concomitant neuromuscular diseases affecting lower limb function.
- renal or liver impairment precluding use of metformin.
- VitaminB12 deficiency
The study team makes the final eligibility decision.
Where it is enrolling
- Hong Kong, Sandy Bay, Hong Kong
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The study runs about 6 months per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Hong Kong, Sandy Bay, Hong Kong. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.