Clinical trial for Major Depression Moderate
Official title rTMS for Youth Inpatients With Depression
ClinicalTrials.gov ID: NCT07140575
What this study is testing
- What it's testing
- This study checks if it is practical and acceptable to give a type of brain stimulation called rTMS twice a day to young people in hospital. It aims to see if this faster schedule helps them get treatment without missing school or other activities.
- Who it's for
- The study is looking for young people aged 15 to 24 who are already in hospital for depression that has not improved with therapy or medication.
- What's involved
- Participants will receive rTMS, a painless treatment that uses magnetic fields to stimulate the brain, twice a day. They will also continue their regular hospital care, including school and therapy sessions.
- Time commitment
- The treatment usually lasts 4 to 6 weeks, with sessions happening five days a week while the participant stays in the hospital.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 14 to 19
You may be able to join if
- age 14-19 years
- primary diagnosis of major depressive disorder or of bipolar I or II disorder, current episode depressed with no psychotic or mixed features
- current episode of depression lasting at least 4 weeks
- failed ≥1 evidence-based psychotherapy or antidepressant
- have a GRID-HAMD-17 (17-item Hamilton Depression Rating Scale) score of ≥16 (moderate-severe range)
You likely can't join if
- lifetime diagnosis of a psychotic disorder, anorexia nervosa, bulimia nervosa diagnosis of a substance use disorder (except caffeine and tobacco)...
- obsessive compulsive disorder or personality disorder that is the main source and driver of distress
- active psychosis and/or mania
- history of epilepsy or any other neurologic condition that includes a history of seizures
- use of medications that lower the seizure threshold
- pregnancy or nursing
See the full eligibility criteria
- age 14-19 years
- primary diagnosis of major depressive disorder or of bipolar I or II disorder, current episode depressed with no psychotic or mixed features
- current episode of depression lasting at least 4 weeks
- failed ≥1 evidence-based psychotherapy or antidepressant
- have a GRID-HAMD-17 (17-item Hamilton Depression Rating Scale) score of ≥16 (moderate-severe range)
- currently an inpatient or suitable for an elective inpatient admission
- lifetime diagnosis of a psychotic disorder, anorexia nervosa, bulimia nervosa diagnosis of a substance use disorder (except caffeine and tobacco) within the past year
- obsessive compulsive disorder or personality disorder that is the main source and driver of distress
- active psychosis and/or mania
- history of epilepsy or any other neurologic condition that includes a history of seizures
- use of medications that lower the seizure threshold
- pregnancy or nursing
- history of severe headaches within the previous year
- improvement in depressive symptom severity between screening and baseline by 25% or more
- inability to adhere to the protocol
The study team makes the final eligibility decision.
Where it is enrolling
- Toronto, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 14 years to 19 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Toronto, Ontario, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.