Critical Illness study: Magnesium oxide vs Magnesium glucoheptonate
Official title Effect of Protocolized Magnesium Replacement on Mortality and Atrial Fibrillation in Critically Ill Patients
ClinicalTrials.gov ID: NCT07173855
What this study is testing
What is Magnesium sulfate?
An investigational protocol for magnesium replacement being studied to see if higher or lower blood magnesium targets improve 30‑day survival and reduce atrial fibrillation in critically ill patients. Magnesium sulfate is designed to raise magnesium levels in the blood, supporting many cellular functions.
Also referred to as Epsom salt.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study aims to find out if giving magnesium to reach a higher blood level leads to better 30-day survival and less atrial fibrillation (an irregular heart rhythm) compared to a lower target level.
- Who it's for
- The study is looking for people who are critically ill, such as those with severe infections, heart attacks, or breathing failure.
- What's involved
- Participants will receive magnesium supplements based on a specific plan. They do not need to do extra tasks, take additional tests, or fill out surveys.
- Time commitment
- The study tracks outcomes for 30 days, but participants do not have to make extra visits or complete specific tasks.
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 16 and older
You may be able to join if
- Age 16 years or older
- Admission orders written to a medical-surgical intensive care unit at a participating site
- Magnesium replacement protocol ordered
You likely can't join if
- Prior enrollment in or withdrawal from MAGNOLIA trial
- Sustained ventricular tachycardia
- Pre-eclampsia
- Myasthenia gravis
The study team makes the final eligibility decision.
Where it is enrolling
- Ajax, Ontario, Canada
- Bowmanville, Ontario, Canada
- Oshawa, Ontario, Canada
- Toronto, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 16 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Ajax, Ontario, Canada; Bowmanville, Ontario, Canada; Oshawa, Ontario, Canada; Toronto, Ontario, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.